| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | METT11D1 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human METTL17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于METTL17抗体的模拟参考文献示例(仅供学术参考，具体文献需根据实际数据库检索确认)：
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1. **文献名称**: *METTL17 regulates mitochondrial ribosomal RNA modification and promotes cancer cell proliferation*
**作者**: Smith A, et al.
**摘要**: 本研究利用METTL17特异性抗体进行免疫印迹和免疫荧光实验，发现METTL17通过甲基化线粒体16S rRNA调控核糖体功能，促进结直肠癌细胞增殖。抗体验证显示其在肿瘤组织中高表达并与患者预后相关。
2. **文献名称**: *Characterization of METTL17 as a mitochondrial methyltransferase involved in heme biosynthesis*
**作者**: Brown L, et al.
**摘要**: 通过抗体验证，研究揭示了METTL17在线粒体中的定位及其在血红素合成通路中的作用。抗体阻断实验表明，METTL17缺失导致血红素前体积累，提示其作为治疗血红素相关疾病的潜在靶点。
3. **文献名称**: *METTL17 interacts with p53 and modulates DNA damage response in human fibroblasts*
**作者**: Garcia R, et al.
**摘要**: 使用METTL17抗体进行免疫共沉淀和ChIP实验，发现其与p53蛋白相互作用，调控DNA损伤应答通路。抗体检测显示METTL17在衰老细胞中表达下调，影响细胞周期停滞。
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**注**：以上文献为模拟示例，实际研究中请通过PubMed、Google Scholar等平台检索具体文献。METTL17相关研究多集中于其甲基转移酶活性、线粒体功能及癌症关联，建议结合关键词“METTL17 antibody”、“methyltransferase”和“mitochondria”进行深入查询。
The METTL17 antibody is a research tool designed to study the methyltransferase-like 17 (METTL17) protein, a member of the methyltransferase superfamily implicated in various cellular processes. METTL17 is evolutionarily conserved and thought to participate in RNA or protein methylation, though its precise substrates and biological functions remain under investigation. Structurally, it contains a conserved Rossmann-fold methyltransferase domain, suggesting its role in transferring methyl groups. Recent studies link METTL17 to mitochondrial function, potentially regulating mitochondrial RNA modification or ribosome assembly, which may influence cellular metabolism, stress responses, and disease pathways.
Antibodies targeting METTL17 enable researchers to detect its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These tools have revealed METTL17's predominant mitochondrial localization and dynamic expression patterns across tissues, with elevated levels in metabolically active organs like the liver and heart. Dysregulation of METTL17 has been tentatively associated with cancers, neurodegenerative disorders, and metabolic syndromes, though mechanistic insights are still emerging.
Validated METTL17 antibodies are critical for exploring its role in development, disease, and potential therapeutic targeting. Ongoing research aims to clarify its molecular mechanisms, including crosstalk with other methyltransferases and impact on mitochondrial homeostasis. As a relatively understudied protein, METTL17 represents a frontier in epitranscriptomics and metabolic regulation research.
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