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Rabbit Polyclonal ETV3 Antibody

  • 中文名: ETV3抗体
  • 别    名: PE1; METS; PE-1; bA110J1.4
货号: IPDX13356
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesPE1; METS; PE-1; bA110J1.4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ETV3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是基于领域知识的模拟参考文献示例,供参考(实际文献请通过学术数据库核实):

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1. **文献名称**: "ETV3 regulates macrophage differentiation and immune response through histone deacetylase activity"

**作者**: Lee, D. et al.

**摘要**: 本研究探讨了ETV3在巨噬细胞分化中的表观遗传调控机制。通过使用兔多克隆ETV3抗体进行染色质免疫沉淀(ChIP)和Western blot分析,发现ETV3通过招募组蛋白去乙酰化酶(HDACs)抑制促炎基因表达,揭示了其在免疫调控中的关键作用。

2. **文献名称**: "Epigenetic silencing of tumor suppressor ETV3 in breast cancer via DNA methylation"

**作者**: Zhang, Y. et al.

**摘要**: 该研究分析了乳腺癌中ETV3的表观遗传失活机制。利用ETV3特异性抗体进行免疫组化(IHC)检测,发现ETV3在肿瘤组织中表达显著降低,且其低表达与患者预后不良相关,提示ETV3可能作为抑癌因子发挥作用。

3. **文献名称**: "ETV3 interacts with the SWI/SNF complex to modulate interferon signaling in viral infections"

**作者**: Sgarbanti, M. et al.

**摘要**: 本文研究了ETV3在病毒感染期间对干扰素通路的调控。通过免疫共沉淀(Co-IP)结合ETV3抗体的实验,发现ETV3与染色质重塑复合物SWI/SNF相互作用,负向调控干扰素刺激基因(ISGs)的表达,影响宿主抗病毒反应。

4. **文献名称**: "Development and validation of a monoclonal antibody specific for ETV3 in hematopoietic malignancies"

**作者**: Kim, H. et al.

**摘要**: 本研究报道了一种新型ETV3单克隆抗体的开发与验证。该抗体在流式细胞术和免疫荧光中表现出高特异性,应用于白血病样本检测显示ETV3异常高表达可能参与疾病进展,为血液肿瘤诊断提供了潜在工具。

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**注意**:以上内容为模拟生成,实际文献需通过PubMed、Web of Science等平台检索确认。建议使用关键词“ETV3 antibody”、“ETV3 immunohistochemistry”或结合具体研究领域进一步筛选。

背景信息

The ETV3 antibody targets the ETS variant transcription factor 3 (ETV3), a member of the ETS family of DNA-binding proteins involved in regulating gene expression. ETV3. also known as METS or PE1. plays roles in cell differentiation, proliferation, and immune response modulation. It interacts with co-repressors like mSin3A and histone deacetylases (HDACs) to repress transcription, influencing pathways such as TGF-β signaling. Research has linked ETV3 to immune regulation, particularly in macrophages and dendritic cells, where it may suppress inflammatory responses. In cancer, ETV3 exhibits dual roles: it acts as a tumor suppressor in some contexts (e.g., breast cancer) by inhibiting oncogenic pathways, while in others (e.g., leukemia), its overexpression correlates with disease progression. Antibodies against ETV3 are critical tools for studying its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and ChIP-seq. Recent studies explore its potential as a therapeutic target or biomarker, given its involvement in epigenetic silencing and tumor microenvironment regulation. Commercial ETV3 antibodies are typically validated for specificity across human and mouse models, aiding translational research in immunology and oncology.

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