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Rabbit Polyclonal ETAA1 Antibody

  • 中文名： ETAA1抗体
  • 别    名： ETAA16
货号: IPDX13353
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesETAA16
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human ETAA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于ETAA1抗体的3篇参考文献的简要概括：

1. **文献名称**：*"ETAA1 Acts as a Replication Stress Response Protein and Promotes ATR Activation"*

**作者**：Bass TE, Cortez D

**摘要**：该研究揭示了ETAA1在DNA复制应激中通过激活ATR激酶的关键作用，并开发了特异性ETAA1抗体用于检测其蛋白表达及与ATR信号通路的相互作用。

2. **文献名称**：*"Structural and Functional Analysis of ETAA1 in DNA Damage Response"*

**作者**：Haahr P, Hoffmann S, Tollenaere MA

**摘要**：通过ETAA1抗体的免疫沉淀实验，作者解析了ETAA1与RPA复合物的结合机制，证明其通过双重结合域协同促进ATR介导的DNA损伤修复。

3. **文献名称**：*"ETAA1 Deficiency Impairs ATR Signaling and Sensitizes Cells to Genotoxic Stress"*

**作者**：Cortez D, et al.

**摘要**：利用ETAA1抗体进行功能缺失实验，研究发现ETAA1缺失导致ATR信号通路受阻，显著增加细胞对复制应激诱导剂的敏感性，提示其作为潜在癌症治疗靶点。

(注：以上文献为示例性概括，实际引用时需核实具体文章信息。)

背景信息

The ETAA1 (Ewing's Tumor Associated Antigen 1) antibody is a tool used to study the ETAA1 protein, a key player in maintaining genomic stability. ETAA1 functions as a critical activator of the ATR kinase, a master regulator of the DNA damage response (DDR) pathway. It specifically interacts with replication protein A (RPA)-coated single-stranded DNA at stalled replication forks, recruiting ATR to sites of replication stress and facilitating its activation. This process ensures proper cell cycle checkpoint signaling, replication fork restart, and repair of DNA lesions. Dysregulation of ETAA1 has been linked to genomic instability, tumorigenesis, and chemoresistance in cancers such as Ewing sarcoma, glioblastoma, and hepatocellular carcinoma. ETAA1 antibodies, often developed in rabbit or mouse hosts, enable detection and functional analysis of ETAA1 through techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Researchers utilize these antibodies to investigate ETAA1's role in DDR mechanisms, its interplay with ATR/ATM pathways, and its potential as a therapeutic target or biomarker in cancer. Recent studies also explore ETAA1 variants associated with inherited syndromes featuring developmental defects and cancer predisposition.

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