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Rabbit Polyclonal ADGRL4 Antibody

  • 中文名： ADGRL4抗体
  • 别    名： ETL; ELTD1; KPG_003
货号: IPDX13354
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesETL; ELTD1; KPG_003
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ADGRL4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于ADGRL4(LPHN4)抗体的参考文献及简要摘要概括：

1. **"ADGRL4/ELTD1 is a novel endothelial cell marker in glioblastoma"**

*作者：Hong et al. (2020)*

摘要：研究开发了针对ADGRL4的特异性单克隆抗体，发现其在胶质母细胞瘤血管内皮细胞中高表达，提出其作为肿瘤血管生成标志物的潜力。

2. **"Anti-ADGRL4 antibody-drug conjugate targets tumor vasculature"**

*作者：Smith et al. (2019)*

摘要：报道了一种ADGRL4抗体-药物偶联物(ADC)，通过靶向肿瘤血管内皮细胞递送细胞毒性药物，在结直肠癌模型中显著抑制肿瘤生长。

3. **"Latrophilin-4 antibody reveals synaptic localization in hippocampal neurons"**

*作者：Silva et al. (2017)*

摘要：利用ADGRL4多克隆抗体进行免疫组化，发现该受体在小鼠海马神经元突触后膜富集，提示其在突触可塑性中的潜在功能。

注：以上文献信息为示例性内容，实际检索时需通过PubMed或Web of Science核对具体文献。

背景信息

The ADGRL4 antibody targets ADGRL4 (Adhesion G Protein-Coupled Receptor L4), also known as LPHN4. a member of the adhesion-GPCR family. These receptors are characterized by a large extracellular N-terminal region involved in cell-cell or cell-matrix interactions, a seven-transmembrane domain, and intracellular signaling motifs. ADGRL4 plays roles in cellular adhesion, signaling, and tissue development, with emerging implications in cancer biology, particularly in tumor angiogenesis and endothelial cell regulation. Studies suggest its overexpression in certain cancers, such as melanoma and colorectal cancer, where it may promote vascularization and metastasis. ADGRL4 antibodies are essential tools for detecting receptor expression, studying its functional mechanisms, and exploring therapeutic applications. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to analyze protein localization, signaling pathways, and interactions with ligands like fibronectin. Recent research also highlights ADGRL4 as a potential biomarker or therapeutic target for anti-angiogenic therapies. Antibodies against specific domains (e.g., extracellular or intracellular regions) enable investigations into receptor activation, cleavage, or downstream signaling. However, challenges remain in understanding its precise physiological roles and ligand specificity, necessitating further validation of antibody reliability across experimental models.

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