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Rabbit Polyclonal UTP18 Antibody

  • 中文名: UTP18抗体
  • 别    名: WDR50; CGI-48
货号: IPDX12927
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesWDR50; CGI-48
WB Predicted band size62 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human UTP18
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于UTP18抗体的模拟参考文献示例(文献信息为虚构,仅供格式参考):

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1. **文献名称**: *UTP18 Antibody Development and Its Role in Ribosome Biogenesis*

**作者**: Zhang Y, et al.

**摘要**: 本研究报道了一种兔源多克隆抗体的制备,特异性靶向人UTP18蛋白。通过Western blot和免疫荧光验证了抗体在HeLa细胞中的适用性,发现UTP18与核仁内rRNA前体加工密切相关,敲低UTP18导致细胞周期G1期阻滞。

2. **文献名称**: *UTP18 Interaction with p53 Signaling Pathway in Cancer Cells*

**作者**: Smith JL, et al.

**摘要**: 利用UTP18抗体进行免疫共沉淀实验,发现UTP18通过与p53相互作用调控核仁应激反应。在结直肠癌细胞中,UTP18高表达与化疗耐药性相关,提示其作为潜在治疗靶点。

3. **文献名称**: *UTP18 Overexpression in Hepatocellular Carcinoma: Prognostic Implications*

**作者**: Wang C, et al.

**摘要**: 采用UTP18抗体对肝癌组织进行免疫组化分析,发现UTP18在肿瘤组织中显著高表达,且与患者不良预后相关。机制研究表明UTP18通过促进核糖体合成加速肿瘤增殖。

4. **文献名称**: *Functional Characterization of UTP18 in Zebrafish Development*

**作者**: Li H, et al.

**摘要**: 通过UTP18抗体阻断实验,发现UTP18在斑马鱼胚胎发育中调控核仁结构和rRNA成熟,缺失导致胚胎发育畸形,证实其在脊椎动物中的保守功能。

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**注意**:以上内容为模拟生成,实际文献需通过PubMed、Google Scholar等平台检索确认。建议使用关键词“UTP18 antibody”、“UTP18 ribosome biogenesis”或“UTP18 cancer”进一步查找真实研究。

背景信息

**Background of UTP18 Antibody**

UTP18 (Uridine Triphosphate 18) is a conserved protein component of the small subunit (SSU) processome, a large ribonucleoprotein complex essential for ribosomal RNA (rRNA) biogenesis. It plays a critical role in the maturation of 18S rRNA, a fundamental step in ribosome assembly, by facilitating the cleavage and modification of precursor rRNA (pre-rRNA) within the nucleolus. Dysregulation of UTP18 has been linked to developmental defects and diseases, including cancer, due to its impact on ribosome synthesis and cellular proliferation.

Antibodies targeting UTP18 are valuable tools for studying ribosome biogenesis, nucleolar organization, and cell cycle dynamics. They are widely used in techniques such as Western blotting, immunofluorescence (IF), and immunoprecipitation (IP) to detect UTP18 expression, localization, and interaction partners. These antibodies help elucidate mechanisms underlying ribosomopathies, cancer progression, and metabolic disorders associated with impaired rRNA processing.

Commercial UTP18 antibodies are typically raised against specific epitopes of human or mouse UTP18. with validation in knockout or knockdown models to ensure specificity. Researchers utilize these reagents to explore how UTP18-mediated rRNA processing influences cellular homeostasis, stress responses, and disease pathways, making them essential for molecular and cell biology research.

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