| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/1000 | Human,Mouse,Rat |
| Aliases | URG4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human URGCP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于URGCP抗体的示例参考文献(内容为模拟虚构，仅作格式参考)：
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1. **文献名称**：*URGCP as a Novel Biomarker in Hepatocellular Carcinoma: Expression and Clinical Significance*
**作者**：Li X, Zhang Y, et al.
**摘要**：本研究通过免疫组化分析发现URGCP在肝癌组织中高表达，且与患者预后不良相关。实验表明URGCP抗体可用于检测肿瘤进展，并提示其可能通过调控Wnt/β-catenin通路促进癌细胞增殖。
2. **文献名称**：*The Role of URGCP in Colorectal Cancer Cell Cycle Regulation*
**作者**：Wang J, Chen H, et al.
**摘要**：利用URGCP抗体进行Western blot和流式细胞术实验，证实URGCP通过结合Cyclin D1调控结肠癌细胞G1/S期转换，沉默URGCP可显著抑制肿瘤生长。
3. **文献名称**：*Development and Validation of a High-Specificity URGCP Monoclonal Antibody*
**作者**：Kim S, Park M, et al.
**摘要**：报道一种新型URGCP单克隆抗体的制备与验证，该抗体在ELISA和免疫荧光中表现出高灵敏度和特异性，适用于多种癌症模型的蛋白定量及定位研究。
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注：以上文献为示例，实际引用请通过PubMed、Google Scholar等平台检索真实发表的研究。
URGCP (Upregulator of Cell Proliferation Gastric Cancer-associated) antibody is a tool used to detect the URGCP protein, which is encoded by the URGCP gene. This gene, located on human chromosome 7. was initially identified for its overexpression in gastric cancer tissues. Studies suggest URGCP plays a role in promoting cell proliferation, survival, and tumor progression by modulating key signaling pathways, including Wnt/β-catenin and PI3K/AKT. Its upregulation correlates with poor prognosis in multiple cancers, including gastric, liver, and breast cancers.
The URGCP antibody is primarily utilized in research to investigate protein expression levels in cancer cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. It helps elucidate URGCP's interaction networks, subcellular localization, and functional mechanisms in oncogenesis. Recent studies also explore its involvement in drug resistance and metastasis.
While commercial URGCP antibodies are available, specificity validation remains critical due to potential cross-reactivity with homologous proteins. Research on URGCP continues to expand, aiming to clarify its potential as a diagnostic biomarker or therapeutic target in precision oncology.
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