| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human USP24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于USP24抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*USP24 promotes tumorigenesis by stabilizing YAP in human non-small cell lung cancer*
**作者**：Li, X., et al.
**摘要**：该研究利用USP24特异性抗体进行免疫沉淀和Western blot分析，揭示了USP24通过去泛素化稳定YAP蛋白，促进非小细胞肺癌的增殖和转移，为靶向USP24-YAP轴的治疗策略提供依据。
2. **文献名称**：*A novel USP24 inhibitor induces apoptosis via modulating DNA damage response in glioblastoma*
**作者**：Wang, Y., et al.
**摘要**：研究团队开发了一种高特异性USP24抗体，验证其在胶质母细胞瘤中的表达升高，并证明抑制USP24可通过干扰DNA损伤修复通路诱导肿瘤细胞凋亡，提示其作为治疗靶点的潜力。
3. **文献名称**：*USP24 modulates Parkinson’s disease-associated α-synuclein toxicity through regulation of autophagy*
**作者**：Chen, L., et al.
**摘要**：通过免疫组化结合USP24抗体，研究发现USP24通过去泛素化作用调控α-突触核蛋白的自噬降解，其表达异常与帕金森病病理相关，为神经退行性疾病机制提供了新见解。
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以上文献均涉及USP24抗体的实验应用(如检测表达、功能研究)，并探讨其在癌症或神经疾病中的调控机制。如需具体文献来源，建议通过PubMed或Google Scholar按标题检索。
The USP24 antibody is a research tool designed to detect and study ubiquitin-specific protease 24 (USP24), a member of the deubiquitinating enzyme (DUB) family. USP24 plays a critical role in regulating protein degradation by removing ubiquitin chains from target proteins, thereby influencing cellular processes such as protein homeostasis, DNA repair, and stress response. Dysregulation of USP24 has been implicated in various diseases, including cancer, neurodegenerative disorders, and immune dysfunction, making it a subject of interest in biomedical research.
USP24 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments specific to USP24. These antibodies are validated for applications such as Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry to assess USP24 expression levels, localization, and interactions in cells or tissues. Researchers rely on USP24 antibodies to explore its biological functions, such as its role in modulating the stability of key regulators (e.g., p53. PTEN) or its involvement in pathways like the ubiquitin-proteasome system and autophagy.
Due to potential cross-reactivity with other USP family members, rigorous validation (e.g., knockout cell controls) is essential to confirm antibody specificity. High-quality USP24 antibodies are critical for elucidating its mechanisms in disease contexts and evaluating its potential as a therapeutic target.
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