| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DRP1; DRP-1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DAPK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DAPK2抗体的参考文献示例(注：以下内容为基于常见研究的模拟示例，非真实文献，建议通过学术数据库核实具体信息)：
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1. **文献名称**: *"Development of a Monoclonal Antibody Against DAPK2 for Apoptosis Detection"*
**作者**: Smith A, et al.
**摘要**: 该研究开发了一种特异性识别DAPK2的单克隆抗体，并通过Western blot和免疫荧光验证其敏感性。结果显示，该抗体能有效检测细胞凋亡过程中DAPK2的激活状态，适用于癌症研究中的凋亡通路分析。
2. **文献名称**: *"DAPK2 Expression and Epigenetic Regulation in Leukemia"*
**作者**: Johnson R, et al.
**摘要**: 研究利用DAPK2抗体分析急性髓系白血病患者样本，发现DAPK2蛋白低表达与DNA甲基化相关，且其缺失预示不良预后，提示DAPK2可能作为表观遗传治疗的潜在靶点。
3. **文献名称**: *"DAPK2 Antibody Validation in Autophagy Studies"*
**作者**: Lee C, et al.
**摘要**: 通过免疫组化和流式细胞术验证了DAPK2抗体的特异性，证明其在自噬研究中的可靠性。实验表明DAPK2通过调控mTOR通路影响自噬，抗体为机制研究提供了工具。
4. **文献名称**: *"Role of DAPK2 in TGF-β-Mediated Fibrosis"*
**作者**: Wang Y, et al.
**摘要**: 使用DAPK2抗体检测血管平滑肌细胞中的蛋白表达，发现DAPK2通过TGF-β信号促进纤维化，抗体为疾病模型中的靶向治疗研究奠定基础。
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建议通过PubMed或Google Scholar搜索关键词“DAPK2 antibody”、“DAPK2 expression”或结合具体研究领域(如癌症、自噬)获取最新文献。
The Death-Associated Protein Kinase 2 (DAPK2) antibody is a tool used to detect and study the DAPK2 protein, a member of the serine/threonine kinase family involved in apoptosis (programmed cell death), autophagy, and immune regulation. DAPK2. structurally characterized by a kinase domain, a calmodulin-binding regulatory region, and a cytoskeletal-binding domain, is regulated by calcium/calmodulin and activated in response to cellular stress signals like oxidative stress or DNA damage. Its role in apoptosis links it to pathways such as TNF-α and Fas signaling, where it promotes cell death under stress conditions.
DAPK2 is implicated in cancer progression, acting as a tumor suppressor in certain contexts. Epigenetic silencing of DAPK2 via promoter hypermethylation has been observed in malignancies like leukemia and lymphoma. Dysregulation of DAPK2 is also associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), where altered expression in lymphocytes may contribute to immune dysfunction. Additionally, it influences inflammatory responses by modulating cytokine production and immune cell activity.
Antibodies targeting DAPK2 are essential in research applications, including Western blotting, immunohistochemistry, and flow cytometry, enabling the study of its expression, localization, and post-translational modifications. These tools help elucidate DAPK2's regulatory mechanisms, such as phosphorylation events or interactions with signaling molecules, and its potential as a therapeutic target or biomarker in cancer and autoimmune disorders.
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