| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MEAI; SCG2 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human MEN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于MEN1抗体的3篇参考文献示例：
---
1. **"Production and characterization of monoclonal antibodies to the MEN1 gene product menin"**
*Author: Guru SC, et al.*
*摘要*：该研究报道了针对MEN1基因编码蛋白menin的单克隆抗体的开发与验证。抗体通过免疫组化和Western blot验证，证实可特异性识别正常组织中的menin，而在MEN1相关肿瘤中表达缺失。
2. **"Menin expression analysis by immunohistochemistry in sporadic endocrine tumors"**
*Author: Agarwal SK, et al.*
*摘要*：利用MEN1抗体对散发性内分泌肿瘤(如胰腺神经内分泌瘤、甲状旁腺瘤)进行免疫组化分析，发现menin蛋白表达缺失与基因突变相关，提示抗体在诊断中的潜在应用价值。
3. **"Nuclear localization of menin and its interaction with proteins in Wnt signaling pathways"**
*Author: Wautot V, et al.*
*摘要*：研究通过免疫荧光和共聚焦显微镜结合MEN1抗体，证实menin蛋白主要定位于细胞核，并参与调控Wnt信号通路相关蛋白的相互作用，为MEN1综合征机制提供新见解。
---
*注：上述文献为示例，实际引用需核实具体来源及细节。建议通过PubMed或Google Scholar以“MEN1 antibody”或“menin antibody”为关键词检索最新研究。*
The MEN1 antibody is a crucial tool in studying the multiple endocrine neoplasia type 1 (MEN1) syndrome, a rare autosomal dominant disorder caused by germline mutations in the *MEN1* tumor suppressor gene. This gene encodes menin, a 610-amino-acid protein involved in transcriptional regulation, genomic stability, and cell cycle control. MEN1 antibodies are designed to detect menin expression in tissues or cell lines, aiding in research on MEN1-associated tumors (e.g., parathyroid adenomas, pancreatic neuroendocrine tumors, and pituitary adenomas). These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to assess menin's localization, expression levels, or loss in tumor samples.
Menin's role in epigenetic modulation and interaction with chromatin-modifying complexes (e.g., histone methyltransferases) has expanded the utility of MEN1 antibodies in studying molecular pathways underlying tumorigenesis. Commercially available MEN1 antibodies are typically validated for specificity using knockout models or siRNA-mediated silencing. Clinically, they may assist in diagnosing MEN1-related tumors or confirming menin loss in sporadic cancers. However, variability in antibody performance across experimental conditions requires careful validation. Research using MEN1 antibodies continues to unravel menin's dual role as a tumor suppressor and oncogenic collaborator in different contexts, highlighting its therapeutic potential.
×
