Rabbit Polyclonal KRTAP11-1 Antibody

The KRTAP11-1 antibody targets the keratin-associated protein 11-1 (KRTAP11-1), a member of the keratin-associated protein (KAP) family. These proteins are critical components of hair and wool fibers, interacting with keratins to form the structural matrix that confers mechanical strength and elasticity to hair shafts. KRTAP11-1. encoded by the *KRTAP11-1* gene within the human hair keratin-associated protein gene cluster on chromosome 21q22.1. is characterized by its cysteine-rich sequences that facilitate disulfide bond formation, stabilizing the hair keratin network. Research on KRTAP11-1 has focused on its role in hair biology, particularly variations influencing hair texture, strength, and susceptibility to disorders like monilethrix or hypotrichosis. Antibodies against KRTAP11-1 are primarily utilized in molecular and histological studies to investigate its expression patterns, localization in hair follicles, and interactions with other structural proteins. They serve as essential tools for understanding genetic regulation of hair formation, disease mechanisms, and potential therapeutic targets for hair-related conditions. Commercial KRTAP11-1 antibodies are typically developed in rabbit or mouse hosts, validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore its broader roles in epithelial biology and potential associations with non-cutaneous pathologies.