关键信息
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基因名
HNRNPA1
- 应用
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别名
HNRPA1; hnRNP-A1; Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP core protein A1; Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P49312
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表达区间
Ser2~Phe320
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分子量
40kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) is a multifunctional protein that plays a crucial role in the regulation of gene expression, RNA splicing, transport, and stability in eukaryotic cells. As a key component of the nuclear RNA-binding protein family, HNRNPA1 is involved in various cellular processes, including the formation of ribonucleoprotein complexes and the modulation of mRNA processing. Research has increasingly focused on HNRNPA1 due to its implications in various diseases, particularly neurodegenerative disorders, where its aggregation has been linked to cellular dysfunction. Additionally, its role in stress granule formation highlights its importance in cellular responses to stress. The study of recombinant HNRNPA1 protein provides a valuable platform for elucidating its structural and functional properties, as well as the molecular mechanisms underlying its involvement in RNA metabolism and disease. Understanding the biophysical characteristics and interactions of HNRNPA1 through recombinant technologies can facilitate the development of targeted therapies and diagnostic tools, making it a significant focus within molecular biology and biomedical research.
