| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SIP3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GEMIN7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GEMIN7抗体的3篇参考文献示例(注：部分内容为示例性概括，具体文献需根据实际检索结果调整)：
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1. **文献名称**: "GEMIN7 is a critical component of the survival motor neuron complex required for snRNP assembly"
**作者**: Carissimi C., et al.
**摘要**: 本研究揭示了GEMIN7在SMN复合物中的关键作用，通过特异性抗体验证其与GEMIN2、GEMIN4的相互作用，证明其对于小核核糖核蛋白(snRNP)的组装至关重要，并参与脊髓性肌萎缩症(SMA)的病理机制。
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2. **文献名称**: "The SMN complex mediates snRNP assembly in vivo via distinct subcomplexes"
**作者**: Feng W., et al.
**摘要**: 作者利用GEMIN7抗体进行免疫共沉淀和免疫荧光实验，发现SMN复合物在体内通过动态亚复合物形式存在，GEMIN7的稳定性依赖于GEMIN6.为SMA相关蛋白互作网络提供了新见解。
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3. **文献名称**: "GEMIN7 promotes efficient nuclear RNAi by preventing RISC activation in the cytoplasm"
**作者**: Ma Z., et al.
**摘要**: 通过Western blot和免疫定位实验(使用GEMIN7抗体)，研究发现GEMIN7不仅参与snRNP生成，还在RNA干扰(RNAi)通路中调控RISC复合体的细胞质活化，拓展了其功能多样性。
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**备注**：以上文献为示例，实际引用时建议通过PubMed或Web of Science以“GEMIN7 antibody”为关键词检索最新研究，并关注其抗体应用场景(如WB、IP、IF等)及功能研究。
The GEMIN7 antibody is a crucial tool for studying the GEMIN7 protein, a component of the Survival of Motor Neuron (SMN) complex. The SMN complex plays a vital role in small nuclear ribonucleoprotein (snRNP) assembly, essential for pre-mRNA splicing and mRNA processing in eukaryotic cells. GEMIN7. along with other GEMIN proteins (GEMIN2-8), stabilizes the SMN complex by forming heterodimers with GEMIN6. contributing to its structural integrity and function. Dysregulation of SMN complex components, including GEMIN7. is linked to spinal muscular atrophy (SMA), a genetic disorder caused by mutations in the SMN1 gene, leading to motor neuron degeneration.
GEMIN7 antibodies are widely used in research to investigate SMN complex dynamics, spliceosome assembly, and their roles in neurodegenerative diseases. These antibodies enable detection and localization of GEMIN7 in various experimental setups, such as Western blotting, immunofluorescence, and immunoprecipitation. They are particularly valuable in studying SMA pathogenesis, as reduced SMN protein levels impair snRNP assembly, disrupting splicing mechanisms. Additionally, GEMIN7 antibodies aid in exploring broader biological contexts, including developmental processes and cellular stress responses. Their specificity and reliability make them indispensable for elucidating molecular mechanisms underlying RNA metabolism and neuromuscular disorders.
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