| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EHT; p85; MTGR1; ZMYND3 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CBFA2T2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CBFA2T2抗体的3篇参考文献信息(格式简化，非真实文献，供参考示例)：
1. **文献名称**：*CBFA2T2 as a Novel Biomarker in Acute Myeloid Leukemia*
**作者**：Smith A, et al. (2020)
**摘要**：研究利用CBFA2T2特异性抗体，通过免疫印迹和免疫组化分析其在AML患者中的表达模式，发现其高表达与特定染色体易位相关，提示其作为白血病分子分型的潜在标志物。
2. **文献名称**：*Characterization of CBFA2T2 Antibodies for Detecting Fusion Proteins in Solid Tumors*
**作者**：Li X, et al. (2018)
**摘要**：开发并验证了一种高亲和力CBFA2T2单克隆抗体，用于检测实体瘤中CBFA2T2-NCOA2融合蛋白，证明其在临床病理诊断中的应用潜力。
3. **文献名称**：*The Role of CBFA2T2 in Transcriptional Repression and Its Interaction with HDACs*
**作者**：Johnson R, et al. (2016)
**摘要**：通过免疫共沉淀(使用CBFA2T2抗体)和ChIP-seq技术，揭示了CBFA2T2通过招募组蛋白去乙酰化酶(HDACs)参与基因沉默的分子机制。
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**注**：以上文献为示例性质，实际引用需通过PubMed或Google Scholar搜索关键词(如“CBFA2T2 antibody”、“CBFA2T2 biomarker”等)获取真实文献。
The CBFA2T2 antibody targets the CBFA2T2 protein (also known as MTG16), a member of the ETO family of nuclear transcriptional corepressors. CBFA2T2 plays critical roles in hematopoietic development, differentiation, and epigenetic regulation by forming complexes with chromatin-modifying enzymes (e.g., histone deacetylases) and transcription factors. It is implicated in transcriptional repression through interactions with DNA-binding proteins like RUNX1.
CBFA2T2 gained prominence due to its involvement in chromosomal translocations in acute myeloid leukemia (AML), particularly the t(16;21)(q24;q22) translocation that fuses CBFA2T2 with RUNX1. disrupting normal hematopoiesis. This fusion protein interferes with myeloid differentiation, contributing to leukemogenesis.
Antibodies against CBFA2T2 are essential tools for studying its expression patterns, subcellular localization, and protein-protein interactions in both normal and malignant cells. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore its tumor-suppressive roles and paradoxical oncogenic behavior in different contexts. Recent research also links CBFA2T2 mutations to solid tumors and neurodevelopmental disorders, expanding its biomedical relevance. These antibodies aid in deciphering CBFA2T2's dual functionality in gene regulation and its potential as a therapeutic target.
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