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| 纯度 | >85%SDS-PAGE. |
| 种属 | Human |
| 靶点 | METRN |
| Uniprot No | Q9UJH8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 24-293aa |
| 氨基酸序列 | GYSEERCSWRGSGLTQEPGSVGQLALACAEGAVEWLYPAGALRLTLGGPDPRARPGIACLRPVRPFAGAQVFAERAGGALELLLAEGPGPAGGRCVRWGPRERRALFLQATPHQDISRRVAAFRFELREDGRPELPPQAHGLGVDGACRPCSDAELLLAACTSDFVIHGIIHGVTHDVELQESVITVVAARVLRQTPPLFQAGRSGDQGLTSIRTPLRCGVHPGPGTFLFMGWSRFGEARLGCAPRFQEFRRAYEAARAAHLHPCEVALH |
| 预测分子量 | 36.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于METRN(Meteorin)重组蛋白的3篇代表性文献摘要(注：内容为模拟虚构，仅供示例参考)：
1. **"Meteorin regulates adipose thermogenesis through IL-4-dependent macrophage activation"**
- **作者**: Lee, S. J., et al.
- **摘要**: 发现METRN重组蛋白通过诱导M2型巨噬细胞分泌IL-4.促进脂肪组织产热和能量代谢，为肥胖治疗提供新靶点。
2. **"Recombinant Meteorin promotes nerve regeneration via the GDNF-RET signaling pathway"**
- **作者**: Jiao, B., et al.
- **摘要**: 研究显示METRN重组蛋白通过激活胶质细胞源性神经营养因子(GDNF)受体RET，促进外周神经损伤后的轴突再生和功能恢复。
3. **"Structural characterization of Meteorin and its role in neuroinflammation"**
- **作者**: Ushach, Y., et al.
- **摘要**: 解析METRN重组蛋白的晶体结构，揭示其通过抑制小胶质细胞NF-κB通路减轻神经炎症反应，可能用于多发性硬化症治疗。
如需真实文献，建议在PubMed或Google Scholar中搜索关键词“Meteorin recombinant protein”或“METRN function”。
METRN (Meteorin) is a secreted protein first identified for its role in neuronal development and synaptic plasticity. It is predominantly expressed in the central nervous system, particularly in astrocytes, and has been implicated in regulating axon guidance, dendritic arborization, and the formation of neural circuits. Subsequent studies revealed its broader physiological functions, including involvement in adipose tissue metabolism, immune modulation, and inflammatory responses. Interestingly, METRN exhibits dual roles depending on cellular context—acting as a neurotrophic factor in the brain while influencing energy expenditure and insulin sensitivity in peripheral tissues.
The recombinant METRN protein is typically produced using eukaryotic expression systems (e.g., mammalian cell lines) to ensure proper post-translational modifications and biological activity. This engineered version retains the native protein's functional domains, enabling researchers to study its mechanisms without interference from endogenous factors. Recent advances in protein purification techniques have improved the yield and stability of recombinant METRN, facilitating both in vitro and in vivo experiments.
Emerging evidence highlights METRN's therapeutic potential across multiple domains. In neurological disorders, it shows neuroprotective effects in models of Alzheimer's disease and spinal cord injury. Its metabolic regulatory properties are being explored for treating obesity and diabetes, particularly through its ability to promote brown adipose tissue activation. Additionally, METRN's immunomodulatory effects on macrophages suggest applications in autoimmune diseases and tissue repair. However, challenges remain in understanding its receptor signaling pathways and tissue-specific functions. Current research focuses on mapping its interaction networks and optimizing delivery methods for clinical translation. As a recombinant tool, METRN continues to provide valuable insights into the crosstalk between neural, metabolic, and immune systems.
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