Recombinant Human MAGEA6 protein

中文名： 黑色素瘤抗原家族A6(MAGEA6)重组蛋白
别名： MAGEA6;MAGE6;Melanoma-associated antigen 6

货号: PA1000-1876

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>85%SDS-PAGE.
种属	Human
靶点	MAGEA6
Uniprot No	P43360
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	1-314aa
氨基酸序列	MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS YPLLHEWALR EGEELEHHHH HH
预测分子量	36 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

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背景信息

**Background of MAGEA6 Recombinant Protein**

The **MAGEA6** (Melanoma Antigen Gene A6) protein belongs to the MAGE family of cancer-testis antigens (CTAs), which are predominantly expressed in germ cells but re-emerge in various malignancies. MAGEA6 is encoded by the *MAGEA6* gene located on the X chromosome and shares high homology with other MAGE-A family members. Its expression is tightly regulated in normal tissues, restricted primarily to the testes, but becomes aberrantly activated in cancers such as melanoma, lung, liver, and breast carcinomas, making it a potential tumor-specific target.

Structurally, MAGEA6 contains a conserved MAGE homology domain (MHD), which facilitates protein-protein interactions. It functions as an oncoprotein by modulating ubiquitin ligase activity, particularly through interactions with E3 RING ligases (e.g., TRIM28), influencing pathways like p53 degradation, Wnt/β-catenin signaling, and apoptosis regulation. These roles contribute to tumor cell survival, proliferation, and chemoresistance.

Recombinant MAGEA6 protein is engineered in vitro using expression systems like *E. coli* or mammalian cells, often tagged with markers (e.g., His-tag) for purification. It serves as a critical tool for studying MAGEA6’s biochemical properties, interaction networks, and immunogenicity. Clinically, MAGEA6 is explored as a target for immunotherapy, including cancer vaccines and T-cell therapies, leveraging its tumor-specific expression to minimize off-target effects. However, challenges remain, such as understanding its regulatory mechanisms and addressing potential autoimmune responses due to shared epitopes with normal proteins.

Research on MAGEA6 recombinant protein continues to advance insights into oncogenesis and therapeutic targeting, bridging gaps between molecular biology and clinical oncology.