| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human MMP24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP24抗体的3篇参考文献示例(内容为虚构，仅供格式参考)：
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1. **文献名称**: *"Development and Characterization of a Monoclonal Antibody Targeting MMP24 for Cancer Research"*
**作者**: Smith A, et al.
**摘要**: 本研究报道了一种新型抗MMP24单克隆抗体的开发与验证。该抗体在Western blot和免疫组化中特异性识别MMP24蛋白，并用于分析其在结直肠癌组织中的表达上调，揭示其与肿瘤转移的相关性。
2. **文献名称**: *"MMP24 (MT5-MMP) in Neural Development: Insights from Immunohistochemical Analysis"*
**作者**: Johnson R, et al.
**摘要**: 通过使用高特异性MMP24抗体进行免疫组织化学染色，研究发现MMP24在小鼠胚胎神经系统的特定神经元中高表达，提示其可能在轴突导向和突触形成中发挥关键作用。
3. **文献名称**: *"Functional Blockade of MMP24 Activity by a Novel Antibody Attenuates Cardiac Fibrosis"*
**作者**: Zhang Y, et al.
**摘要**: 本文开发了一种能中和MMP24酶活性的功能性抗体，并在小鼠心脏纤维化模型中验证其疗效。结果显示，该抗体通过抑制MMP24介导的细胞外基质重塑，显著减缓纤维化进程。
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注：以上文献为示例，实际引用时需检索真实数据库(如PubMed)并核实信息。如需真实文献，建议使用关键词 **"MMP24 antibody"** 或 **"MT5-MMP antibody"** 在学术平台检索。
MMP24 (Matrix Metalloproteinase 24), also known as MT5-MMP, is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. It is characterized by a conserved domain structure, including a propeptide, catalytic, hinge, and hemopexin-like domain. Unlike many MMPs, MMP24 is membrane-anchored via a transmembrane domain or glycosylphosphatidylinositol (GPI) linkage, enabling localized proteolytic activity. It plays roles in neural development, tissue repair, and pathological processes such as cancer progression and neurodegeneration. MMP24 is expressed in the brain, kidneys, and reproductive tissues, with elevated levels observed in glioblastoma, Alzheimer’s disease, and osteoarthritis.
MMP24 antibodies are essential tools for studying its expression, localization, and function. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect MMP24 in biological samples. Some antibodies target specific domains (e.g., catalytic or hemopexin regions) to investigate structure-function relationships or inhibit enzymatic activity. Research highlights MMP24's involvement in activating pro-MMP2 and degrading ECM components like collagen IV, influencing cell migration and invasion. Dysregulation of MMP24 is linked to tumor metastasis and neuroinflammation, making it a potential therapeutic target. Antibodies against MMP24 aid in elucidating its mechanisms in disease models and validating its role as a biomarker or drug candidate.
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