Rabbit Polyclonal MYOZ2 Antibody

MYOZ2 (myozenin-2), also known as calsarcin-1. is a striated muscle-specific protein predominantly expressed in cardiac and skeletal muscle. It belongs to the myozenin family of Z-disc proteins, which anchor structural and signaling molecules within muscle sarcomeres. MYOZ2 interacts with calcineurin, α-actinin, and γ-filamin, playing roles in muscle differentiation, mechanical stress response, and regulation of calcineurin-mediated signaling pathways linked to hypertrophy. Antibodies targeting MYOZ2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. Research applications include immunohistochemistry, Western blotting, and immunofluorescence to investigate MYOZ2's involvement in cardiac remodeling, cardiomyopathies, and muscular dystrophies. Altered MYOZ2 expression has been associated with hypertrophic cardiomyopathy (HCM), Duchenne muscular dystrophy, and exercise-induced muscle adaptation. MYOZ2 antibodies also aid in exploring its role as a potential biomarker or therapeutic target. Commercial antibodies are typically validated for specificity using knockout controls or peptide blocking assays. Cross-reactivity with other myozenin isoforms (MYOZ1. MYOZ3) should be considered during experimental design. Studies using MYOZ2 antibodies have advanced understanding of Z-disc organization and calcium-dependent signaling in striated muscles.