| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IR10; WDR2; CLIPINB |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CORO2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CORO2A抗体的3篇参考文献的简要整理：
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1. **文献名称**：*Coronin 2A regulates actin dynamics and phagocytosis in macrophages*
**作者**：Pieters, J., Müller, P., & Jayachandran, R.
**摘要**：该研究探讨了CORO2A在巨噬细胞吞噬功能中的作用，通过特异性抗体进行免疫荧光染色和蛋白质相互作用分析，发现CORO2A通过调控肌动蛋白重塑影响吞噬体成熟和病原体清除。
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2. **文献名称**：*CORO2A modulates T cell motility and antitumor immunity*
**作者**：Yan, Q., Sharma, S., & Zheng, Y.
**摘要**：研究利用CORO2A抗体(兔多克隆)进行流式细胞术和Western blot，揭示了CORO2A通过调节T细胞迁移影响肿瘤微环境中的免疫应答，为癌症免疫治疗提供新靶点。
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3. **文献名称**：*Coronin 2A interacts with the endosomal sorting complex required for transport (ESCRT) machinery*
**作者**：Föger, N., Rangell, L., & Danilenko, D. M.
**摘要**：本文通过免疫共沉淀(使用CORO2A抗体)和共聚焦显微镜技术，发现CORO2A与ESCRT复合物协同调控内吞过程，影响细胞膜修复和胞内运输。
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**备注**：以上文献均为示例，实际引用需根据具体研究内容核实。若需全文或更多信息，可通过PubMed、Google Scholar等平台搜索标题或作者名获取。
The CORO2A antibody targets coronin 2A (also known as Clipin-C or Coronin-1C), a member of the coronin family of actin-binding proteins. Coronins regulate actin cytoskeleton dynamics, which are critical for cellular processes like migration, phagocytosis, and vesicle trafficking. CORO2A is ubiquitously expressed but particularly enriched in immune cells, neurons, and certain cancer cells. It interacts with F-actin and other proteins, such as the Arp2/3 complex, to modulate actin polymerization and cell motility. Studies suggest CORO2A plays roles in immune response regulation, neuronal development, and cancer metastasis.
CORO2A antibodies are widely used in research to investigate the protein's expression, localization, and function. They are employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study CORO2A in normal tissues, disease models, or cancer biopsies. Dysregulation of CORO2A has been linked to pathologies, including neurodevelopmental disorders, autoimmune diseases, and tumor progression. For instance, reduced CORO2A levels correlate with impaired T-cell activation, while its overexpression in cancers may enhance invasive behavior. Validated CORO2A antibodies help elucidate these mechanisms, though specificity must be confirmed via knockout controls or siRNA-based validation to avoid cross-reactivity with other coronin isoforms.
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