Rabbit Polyclonal COPS8 Antibody

The COPS8 antibody is a research tool designed to detect the COP9 signalosome subunit 8 (COPS8), a critical component of the COP9 signalosome (CSN) complex. The CSN is a highly conserved, multi-protein complex involved in regulating ubiquitin-proteasome system-mediated protein degradation, primarily through its interaction with cullin-RING E3 ubiquitin ligases (CRLs). COPS8. also known as CSN8. is one of the eight core subunits (CSN1–CSN8) that constitute the CSN complex. This subunit plays a role in stabilizing the complex and modulating its deneddylase activity, which is essential for maintaining CRL function and substrate specificity. Dysregulation of COPS8 has been linked to cellular processes such as cell cycle progression, DNA damage response, and apoptosis, with implications in cancer, neurodegenerative disorders, and immune diseases. Antibodies targeting COPS8 are widely used in molecular biology to study its expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. They are particularly valuable in elucidating the role of the CSN complex in protein homeostasis, signal transduction, and disease mechanisms, making COPS8 antibodies indispensable in both basic research and translational studies.