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Rabbit Polyclonal CBFB Antibody

  • 中文名: CBFB抗体
  • 别    名: PEBP2B
货号: IPDX02462
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesICH; HANAC; POREN1; arresten
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human COL4A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CBFB抗体的3篇代表性文献示例(注:文献信息为假设性示例,具体引用请通过学术数据库核实):

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1. **文献名称**:*"CBFB Antibody Validation in Acute Myeloid Leukemia Diagnostics"*

**作者**:Smith A, et al.

**摘要**:本研究验证了CBFB抗体的特异性在急性髓系白血病(AML)样本中的应用,通过免疫组化和Western blot证实其在检测CBFB-MYH11融合蛋白中的可靠性,为AML分子分型提供工具。

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2. **文献名称**:*"Role of CBFB in Hematopoietic Differentiation Revealed by Antibody-Based Knockdown"*

**作者**:Chen L, et al.

**摘要**:利用CBFB特异性抗体进行功能阻断实验,揭示CBFB在造血干细胞分化中的关键作用,并证明其与RUNX1的相互作用对维持正常造血至关重要。

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3. **文献名称**:*"Development of a Monoclonal Antibody Targeting CBFB for Cancer Research"*

**作者**:Tanaka K, et al.

**摘要**:报道了一种高亲和力CBFB单克隆抗体的开发,通过流式细胞术和免疫荧光验证其在乳腺癌和白血病细胞系中的表达定位,支持CBFB作为肿瘤标志物的研究。

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如需具体文献,建议在 **PubMed** 或 **Google Scholar** 搜索关键词:`CBFB antibody validation`、`CBFB immunohistochemistry` 或 `CBFB leukemia`。实际研究中,可参考《Blood》《Cancer Research》等期刊的相关论文。

背景信息

The CBFB (Core Binding Factor Beta) antibody is a crucial tool in studying the CBFB protein, a key component of the core-binding factor (CBF) complex. CBFB forms a heterodimer with RUNX family transcription factors (RUNX1. RUNX2. RUNX3), enhancing their DNA-binding affinity and stability. This complex regulates hematopoietic differentiation, skeletal development, and cellular proliferation. Dysregulation of CBFB, particularly through chromosomal translocations like inv(16)(p13q22) in acute myeloid leukemia (AML), leads to fusion proteins (e.g., CBFB-MYH11) that disrupt normal hematopoiesis. Antibodies targeting CBFB are widely used in research to detect its expression, localization, and interactions via techniques such as Western blot, immunohistochemistry, and co-immunoprecipitation. They also aid in studying CBFB's role in diseases, including leukemia, solid tumors, and developmental disorders. CBFB antibodies are essential for exploring molecular mechanisms in gene regulation, disease pathogenesis, and therapeutic targeting.

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