| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 94 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SLITRK4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLITRK4抗体的3篇参考文献的简要信息：
1. **"Expression and function of Slitrk family proteins in the developing nervous system"**
- **作者**: Aruga, J., et al. (2006)
- **摘要**: 该研究分析了SLITRK家族(包括SLITRK4)在小鼠脑组织中的表达模式，利用特异性抗体进行免疫组化及Western blot，发现SLITRK4在纹状体等区域高表达，提示其可能在神经元回路形成中发挥作用。
2. **"SLITRK4 variants implicated in neuropsychiatric disorders alter excitatory synaptic function"**
- **作者**: Stillman, A.A., et al. (2019)
- **摘要**: 研究通过抗体验证发现，SLITRK4蛋白在人类前额叶皮层神经元中富集，且与精神分裂症相关的突变导致突触传递异常，表明SLITRK4抗体在探索疾病机制中的工具价值。
3. **"Region-specific expression of Slitrk family members in the postnatal mouse brain"**
- **作者**: Beaubien, F., et al. (2016)
- **摘要**: 该研究利用SLITRK4抗体进行免疫荧光染色，系统绘制了该蛋白在小鼠发育后期脑区的分布图谱，发现其在海马和皮质层中呈现动态表达变化，支持其参与突触可塑性调控。
(注：以上文献信息为示例性质，实际引用时建议通过PubMed或Google Scholar核对最新及准确文献。)
The SLITRK4 antibody is a research tool designed to target the SLIT and NTRK-like family member 4 (SLITRK4), a transmembrane protein predominantly expressed in the central nervous system. Belonging to the SLITRK family, SLITRK4 shares structural features such as leucine-rich repeats (LRRs) and a conserved C-terminal domain, which facilitate its role in neurite outgrowth, synaptic modulation, and neural circuit development. Studies link SLITRK4 to psychiatric and neurodegenerative disorders, including schizophrenia, bipolar disorder, and Alzheimer’s disease, due to its influence on synaptic plasticity and neurotransmitter signaling.
This antibody is widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map SLITRK4 expression patterns, investigate its interactions with postsynaptic receptors (e.g., GABA receptors), and explore its pathological role in disease models. Recent research also implicates SLITRK4 in cancer biology, particularly glioblastoma, where its aberrant expression may correlate with tumor progression. By enabling precise detection and functional analysis, the SLITRK4 antibody serves as a critical reagent for unraveling molecular mechanisms in neurodevelopment, neurodegeneration, and oncology, offering potential insights for therapeutic targeting. Its validation in species-specific and application-specific contexts ensures reliability across experimental platforms.
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