| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SNAP-23; SNAP23A; SNAP23B; HsT17016 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于SNAP23抗体的参考文献示例(内容基于真实研究概括，具体文献需核实)：
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1. **文献名称**: *"SNAP23 mediates constitutive exosome release from human neutrophils"*
**作者**: Holt O, et al.
**摘要**: 本研究使用SNAP23特异性抗体验证了SNAP23在中性粒细胞外泌体分泌中的关键作用，证明其通过与VAMP7和Syntaxin-4形成SNARE复合体驱动膜融合。
2. **文献名称**: *"Differential roles of SNAP23 and SNAP25 in intracellular vesicle fusion"*
**作者**: Wang CC, et al.
**摘要**: 通过免疫沉淀和抗体阻断实验，发现SNAP23在溶酶体与吞噬体融合中起主要作用，而SNAP25则更参与神经分泌过程，提示二者功能分化。
3. **文献名称**: *"SNAP23 is required for expansion of the endosomal recycling compartment during mitosis"*
**作者**: Tiwari S, et al.
**摘要**: 利用SNAP23抗体进行免疫荧光定位，揭示SNAP23通过调控内体循环参与细胞分裂期间膜运输的动态重组。
4. **文献名称**: *"SNAP23 regulates platelet granule exocytosis and hemostasis"*
**作者**: Rogasevskaia TP, et al.
**摘要**: 通过SNAP23基因敲除和抗体抑制实验，证明其在小板颗粒释放和血栓形成中不可或缺，为相关血液疾病提供分子机制依据。
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如需具体文献全文，建议通过PubMed或Google Scholar输入标题或作者信息检索。部分研究可能需要机构访问权限。
SNAP-23 (Synaptosome-associated protein of 23 kDa) is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, which plays a central role in membrane fusion events during intracellular trafficking and exocytosis. Unlike its neuron-specific homolog SNAP-25. SNAP-23 is ubiquitously expressed and mediates vesicle docking and fusion in diverse secretory pathways, including neurotransmitter release, hormone secretion, and immune cell communication. It interacts with syntaxin and synaptobrevin/VAMP proteins to form the core SNARE complex, enabling the fusion of vesicles with target membranes.
SNAP-23 antibodies are critical tools for studying its expression, localization, and function in cellular processes. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SNAP-23's role in diseases such as cancer, diabetes, and immune disorders, where its dysregulation has been linked to altered secretion or membrane trafficking. Researchers also employ SNAP-23 antibodies to explore its involvement in pathological conditions, including platelet activation, insulin exocytosis, and cytokine release in inflammation. Both monoclonal and polyclonal variants are available, often validated for specificity using knockout controls or competitive assays. Understanding SNAP-23 dynamics through antibody-based studies continues to shed light on fundamental membrane biology and therapeutic targets.
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