Rabbit Polyclonal PMPCB Antibody

The PMPCB (Peptidase, Mitochondrial Processing Subunit Beta) antibody targets a key component of the mitochondrial processing peptidase (MPP), essential for mitochondrial protein maturation. MPP, composed of PMPCB (β-subunit) and PMPCA (α-subunit), cleaves N-terminal targeting presequences from nuclear-encoded mitochondrial precursor proteins, enabling their proper folding and function within mitochondria. This proteolytic activity is critical for mitochondrial biogenesis, energy metabolism, and cellular homeostasis. PMPCB antibodies are widely used in research to study mitochondrial protein import mechanisms, assess MPP expression levels, and investigate mitochondrial dysfunction linked to neurodegenerative diseases, metabolic disorders, or cancer. They are applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize PMPCB localization in mitochondrial matrix or monitor its dynamic regulation under stress conditions. Commercial PMPCB antibodies are typically raised against specific epitopes (e.g., human PMPCB residues 450-500) and validated for cross-reactivity in common model organisms. Recent studies also explore PMPCB's role beyond processing, including its interaction with respiratory chain complexes and potential involvement in apoptosis, highlighting its broader significance in mitochondrial health and disease pathology.