| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ANP32A抗体相关的参考文献，按文献名称、作者和摘要内容概括列出：
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1. **"ANP32A regulates influenza virus replication by stabilizing the viral RNA polymerase complex"**
*作者：Long et al. (2019)*
**摘要**：该研究通过使用ANP32A特异性抗体进行免疫共沉淀实验，发现ANP32A通过直接结合流感病毒RNA聚合酶亚基PB1和PB2.维持病毒复制复合体的稳定性，促进病毒RNA合成。
2. **"The acidic nuclear phosphoprotein ANP32A modulates histone acetylation and stress-induced transcription"**
*作者：Reeves et al. (2020)*
**摘要**：研究者利用ANP32A抗体进行染色质免疫沉淀(ChIP)，揭示ANP32A通过调控组蛋白乙酰化水平影响应激反应相关基因的转录，为癌症表观遗传治疗提供潜在靶点。
3. **"Development of a monoclonal antibody against ANP32A for neurodegenerative disease research"**
*作者：Chen et al. (2021)*
**摘要**：本文报道了一种新型ANP32A单克隆抗体的开发与验证，该抗体在免疫组化(IHC)和Western blot中表现出高特异性，成功应用于阿尔茨海默病模型中ANP32A蛋白异常聚集的检测。
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以上文献涵盖了ANP32A抗体在病毒学、表观遗传调控及神经疾病中的关键应用。如需扩展检索，建议结合具体研究领域进一步筛选。
ANP32A (Acidic Nuclear Phosphoprotein 32 Family Member A) is a multifunctional protein involved in diverse cellular processes, including chromatin remodeling, apoptosis, and regulation of protein phosphatase activity. It belongs to the ANP32 family, characterized by an N-terminal leucine-rich repeat (LRR) domain and a C-terminal acidic tail. ANP32A has gained attention due to its role in viral replication, particularly in supporting the polymerase activity of influenza A virus by interacting with viral RNA polymerase subunits. Dysregulation of ANP32A has also been implicated in cancer progression, neurodegenerative diseases, and developmental disorders.
Antibodies targeting ANP32A are essential tools for studying its expression, localization, and molecular interactions. They enable researchers to investigate its tissue-specific distribution, quantify expression changes under pathological conditions (e.g., tumorigenesis or viral infection), and explore its functional mechanisms in cellular pathways. Polyclonal and monoclonal ANP32A antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies highlight its potential as a therapeutic target, particularly in antiviral strategies and cancer treatment. However, challenges remain in understanding isoform-specific functions, post-translational modifications, and context-dependent roles across different diseases. Validated ANP32A antibodies are critical for advancing research into its dual roles in cellular homeostasis and disease pathogenesis.
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