| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | FDFACT1; FDFACT2 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PILRB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PILRB抗体的3篇参考文献示例(文献信息为模拟内容，实际需根据具体研究补充)：
---
1. **文献名称**: *"PILRB signaling modulates autoimmune neuroinflammation by regulating T cell activation"*
**作者**: Smith A, et al.
**摘要**: 研究揭示了PILRB在调节T细胞活化和自身免疫性脑脊髓炎(EAE)中的作用，发现PILRB抗体通过阻断受体信号通路抑制炎症反应，为多发性硬化症治疗提供潜在靶点。
2. **文献名称**: *"Structural basis of PILRB-mediated immune inhibitory signaling"*
**作者**: Chen L, et al.
**摘要**: 通过X射线晶体学解析了PILRB与配体及抗体的复合物结构，阐明其抑制性信号传导机制，为开发靶向PILRB的抗体药物奠定结构基础。
3. **文献名称**: *"Anti-PILRB antibodies enhance macrophage phagocytosis in cancer models"*
**作者**: Wang Y, et al.
**摘要**: 研究证明抗PILRB抗体可通过阻断肿瘤微环境中的免疫抑制信号，增强巨噬细胞对癌细胞的吞噬能力，提示其在癌症免疫治疗中的应用潜力。
---
注：以上为模拟文献，实际引用时请通过PubMed、Web of Science等平台检索真实研究。
The paired immunoglobulin-like type 2 receptor beta (PILRB) is a cell surface receptor belonging to the immunoglobulin superfamily, primarily expressed on immune cells such as macrophages, neutrophils, and dendritic cells. It interacts with ligands like PILRA (its paired receptor) and certain glycosylated proteins, playing roles in immune regulation, cell signaling, and inflammatory responses. PILRB is implicated in modulating both activating and inhibitory pathways, with its cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit phosphatases to dampen cellular activation.
PILRB antibodies are tools developed to study receptor-ligand interactions, downstream signaling, and its involvement in diseases. Research highlights its association with neuroinflammatory conditions (e.g., Alzheimer’s disease) and autoimmune disorders, where dysregulated PILRB activity may contribute to pathological inflammation or immune evasion. Antibodies targeting PILRB are utilized in functional assays (e.g., blocking ligand binding), flow cytometry, and immunohistochemistry to explore its expression patterns and therapeutic potential. Recent studies also investigate PILRB's role in cancer immunity and viral infections, as some pathogens exploit PILRB-related pathways to evade immune detection. Challenges include understanding receptor redundancy and species-specific differences, as murine PILRB homologs differ functionally from human counterparts. These antibodies hold promise for dissecting immune modulation mechanisms and developing targeted therapies.
×
