Rabbit Polyclonal PPP1CB Antibody

The PPP1CB antibody is a crucial tool in studying the protein phosphatase 1 catalytic subunit beta (PPP1CB), a member of the serine/threonine phosphatase family. PPP1CB plays a pivotal role in regulating diverse cellular processes, including cell cycle progression, signal transduction, glycogen metabolism, and neuronal signaling, by dephosphorylating target proteins. It forms complexes with regulatory subunits to achieve substrate specificity and functional diversity. Dysregulation of PPP1CB has been linked to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Researchers use PPP1CB antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and interactions in various tissues and cell lines. These antibodies are often validated for specificity against recombinant PPP1CB or through knockout controls to ensure accurate detection. Commercially available PPP1CB antibodies are typically produced in hosts like rabbits or mice, with options for monoclonal or polyclonal formats. Their applications extend to investigating PPP1CB's role in cellular stress responses, apoptosis, and its interplay with kinases in maintaining phosphorylation balance. Reliable PPP1CB antibodies are essential for elucidating its pathophysiological mechanisms and potential therapeutic targeting.