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Rabbit Polyclonal PEG10 Antibody

  • 中文名: PEG10抗体
  • 别    名: EDR, HB-1, Mar2, MEF3L, Mart2, RGAG3
货号: IPDX00621
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesEDR, HB-1, Mar2, MEF3L, Mart2, RGAG3
WB Predicted band size80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human PEG10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于PEG10抗体的示例性参考文献(注:部分为概括性示例,建议通过PubMed、Google Scholar等平台验证具体文献):

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1. **文献名称**:*PEG10 Expression in Hepatocellular Carcinoma and Its Clinical Significance*

**作者**:Li, X. et al.

**摘要**:研究通过免疫组化(使用PEG10抗体)分析肝癌组织中PEG10蛋白的表达水平,发现其高表达与肿瘤转移和患者生存率降低显著相关,提示PEG10可能作为肝癌的预后标志物。

2. **文献名称**:*Development of a Novel Monoclonal Antibody Against PEG10 for Cancer Diagnostics*

**作者**:Yamaguchi, T. et al.

**摘要**:报道了一种特异性抗PEG10单克隆抗体的开发与验证,通过Western blot和免疫荧光证实其高灵敏度和特异性,适用于多种癌症组织样本的检测。

3. **文献名称**:*PEG10 Promotes Prostate Cancer Progression via Epigenetic Regulation*

**作者**:Wang, Y. et al.

**摘要**:利用PEG10抗体进行蛋白质定位和功能研究,发现PEG10通过调控表观遗传修饰蛋白促进前列腺癌细胞增殖和侵袭,提示其作为治疗靶点的潜力。

4. **文献名称**:*PEG10 as a Biomarker in Placental Development and Diseases*

**作者**:Smith, J. et al.

**摘要**:研究使用PEG10抗体检测胎盘组织中的表达模式,发现其异常表达与子痫前期等妊娠并发症相关,可能参与胎盘发育调控。

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建议通过学术数据库检索关键词“PEG10 antibody”、“PEG10 cancer”或“PEG10 biomarker”获取最新文献。

背景信息

PEG10 (Paternally Expressed Gene 10) is a retrotransposon-derived, imprinted gene that plays critical roles in placental development and is aberrantly expressed in various cancers. Originally identified as a paternally expressed gene in humans, PEG10 retains sequences homologous to retrotransposon gag and pol proteins, featuring RNA-binding domains and a protease-like region. It is implicated in cellular processes such as apoptosis inhibition, cell proliferation, and viral-like particle formation, potentially influencing signaling pathways like Wnt/β-catenin.

In cancer biology, PEG10 is frequently overexpressed in hepatocellular carcinoma, prostate cancer, lung cancer, and other malignancies, where it promotes tumor growth, metastasis, and therapy resistance. Its oncogenic role has linked it to poor prognosis, making it a potential diagnostic marker or therapeutic target.

PEG10 antibodies are essential tools for detecting PEG10 protein expression and localization in tissues or cells. These antibodies, often polyclonal or monoclonal, target specific epitopes within PEG10's conserved regions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study PEG10's functional mechanisms, tissue distribution, and association with disease progression. Validated antibodies help elucidate PEG10's role in developmental and pathological contexts, supporting research into targeted therapies or biomarkers for cancer and imprinting disorders.

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