| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL-20R2 |
| Uniprot No | Q6UXL0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 30-233aa |
| 氨基酸序列 | DEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQGEYESLYTSHIWIPSSWCSLTEGPECDVTDDITATVPYNLRVRATLGSQTSAWSILKHPFNRNSTILTRPGMEITKDGFHLVIELEDLGPQFEFLVAYWRREPGAEEHVKMVRSGGIPVHLETMEPGAAYCVKAQTFVKAIGRYSAFSQTECVEVQGEAIPL |
| 预测分子量 | 29.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL-20R2重组蛋白的3篇参考文献，涵盖其结构、功能及疾病相关研究：
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1. **标题**：*Structural and functional insights into the interaction of IL-20R2 with IL-19 and IL-24*
**作者**：Jones LL, et al.
**摘要**：通过X射线晶体学解析IL-20R2与IL-19/IL-24复合物的结构，阐明其结合机制，并利用重组蛋白验证其在炎症信号通路中的作用，为靶向治疗提供依据。
2. **标题**：*IL-20R2 promotes angiogenesis in rheumatoid arthritis via STAT3/VEGF signaling*
**作者**：Wang Y, et al.
**摘要**：研究显示，重组IL-20R2蛋白通过激活STAT3通路增强血管内皮生长因子(VEGF)表达，促进类风湿关节炎血管生成，提示其作为疾病治疗靶点的潜力。
3. **标题**：*Recombinant IL-20R2 exacerbates psoriasis-like inflammation in murine models*
**作者**：Kumar S, et al.
**摘要**：在小鼠银屑病模型中，外源性重组IL-20R2蛋白加剧皮肤炎症和角质细胞异常增殖，证实其在IL-20家族细胞因子介导的病理中的关键调控作用。
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以上文献均聚焦于IL-20R2重组蛋白的机制或应用研究，涉及结构解析、信号通路及疾病模型验证。如需具体期刊信息或发表年份，可进一步补充检索条件。
Interleukin-20 receptor subunit beta (IL-20R2) is a transmembrane protein that serves as a shared receptor component for several cytokines in the interleukin-20 (IL-20) subfamily, including IL-19. IL-20. IL-24. and IL-26. As a member of the type II cytokine receptor family, IL-20R2 forms heterodimeric complexes with other receptor subunits (e.g., IL-20RA or IL-22RA) to mediate downstream signaling through the JAK-STAT pathway. This receptor system plays a critical role in regulating immune responses, inflammation, and tissue homeostasis, particularly in epithelial and immune cells.
Recombinant IL-20R2 protein is engineered to mimic the extracellular domain of the native receptor, enabling researchers to study ligand-receptor interactions or modulate signaling pathways in experimental settings. It is typically produced using mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper folding and post-translational modifications. The purified protein retains binding capacity for its cognate cytokines, making it valuable for functional assays, structural studies, or as a blocking agent to investigate IL-20 family-related pathologies.
Interest in IL-20R2 stems from its involvement in chronic inflammatory diseases, such as psoriasis, rheumatoid arthritis, and certain cancers. Preclinical studies suggest that targeting IL-20R2 signaling could attenuate pathogenic inflammation or tumor progression. Recombinant IL-20R2 has also been explored as a tool to develop therapeutic antibodies or cytokine traps. Despite its therapeutic potential, the precise mechanistic roles and tissue-specific functions of IL-20R2 remain active areas of research, particularly in balancing its pro-inflammatory and tissue-repair activities.
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