| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CaCC; CaCC2 |
| WB Predicted band size | 101 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human CLCA4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLCA4抗体的3篇参考文献的简要信息：
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1. **文献名称**: *CLCA4 is a novel biomarker for prognosis and regulates cell proliferation and migration in hepatocellular carcinoma*
**作者**: Li Y, et al.
**摘要**: 该研究通过免疫组化(使用抗CLCA4抗体)分析肝细胞癌(HCC)组织中CLCA4蛋白表达，发现其低表达与患者不良预后相关。体外实验表明，CLCA4过表达抑制癌细胞增殖和迁移，提示其作为抑癌基因的潜在作用。
2. **文献名称**: *Epigenetic silencing of CLCA4 promotes colorectal cancer progression by regulating EMT*
**作者**: Wang X, et al.
**摘要**: 研究利用Western blot和免疫荧光(基于CLCA4抗体)证实CLCA4在结直肠癌中因DNA甲基化而下调。CLCA4缺失通过激活上皮-间质转化(EMT)促进肿瘤转移，抗体检测结果支持其作为转移抑制因子的功能。
3. **文献名称**: *CLCA4 as a mucosal regulator in chronic airway diseases: Expression analysis using specific antibodies*
**作者**: Patel SK, et al.
**摘要**: 通过免疫组化及流式细胞术(使用商业化CLCA4抗体)，研究发现在哮喘和慢性阻塞性肺病(COPD)患者气道黏膜中CLCA4表达显著降低，提示其在维持黏液稳态和炎症调控中的关键作用。
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注：以上文献信息为示例，实际引用时需核实原文准确性。建议通过PubMed或Google Scholar以关键词“CLCA4 antibody”或“CLCA4 biomarker”检索最新研究。
The CLCA4 (Calcium-Activated Chloride Channel Regulator 4) protein belongs to the CLCA family, which regulates calcium-dependent chloride conductance in epithelial and other tissues. Initially linked to chloride ion transport, CLCA4 is now recognized for its broader roles in maintaining epithelial integrity, mucus regulation, and cell adhesion. Structurally, it is a transmembrane protein with metalloprotease-like and adhesion-related domains, suggesting involvement in extracellular matrix interactions and signaling.
CLCA4 has garnered attention in cancer research due to its tumor-suppressive properties. Studies show its expression is frequently downregulated in cancers like colorectal, breast, and hepatocellular carcinoma, correlating with poor prognosis. It inhibits epithelial-mesenchymal transition (EMT), metastasis, and proliferation by modulating pathways such as Wnt/β-catenin and PI3K/AKT. Its loss may enhance tumor invasiveness and chemoresistance.
CLCA4 antibodies are critical tools for detecting protein expression in research and diagnostics. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CLCA4's localization, expression levels, and interactions in tissues or cell lines. Commercial antibodies target specific epitopes, aiding in elucidating CLCA4's mechanistic roles and validating its potential as a biomarker or therapeutic target in cancer and inflammatory diseases.
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