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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1qtnf12 |
| Uniprot No | Q5T7M4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 21-302aa |
| 氨基酸序列 | GGVGARREAQRTQQPGQRADPPNATASASSREGLPEAPKPSQASGPEFSDAHMTWLNFVRRPDDGALRKRCGSRDKKPRDLFGPPGPPGAEVTAETLLHEFQELLKEATERRFSGLLDPLLPQGAGLRLVGEAFHCRLQGPRRVDKRTLVELHGFQAPAAQGAFLRGSGLSLASGRFTAPVSGIFQFSASLHVDHSELQGKARLRARDVVCVLICIESLCQRHTCLEAVSGLESNSRVFTLQVQGLLQLQAGQYASVFVDNGSGAVLTIQAGSSFSGLLLGT |
| 预测分子量 | 36.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于C1qtnf12(CTRP12)重组蛋白的模拟参考文献示例(内容为模拟生成，非真实文献)：
1. **"C1qtnf12 recombinant protein enhances insulin sensitivity in obese mice"**
*作者：Zhang Y, et al.*
摘要：研究通过表达纯化C1qtnf12重组蛋白，发现其通过激活AMPK通路改善高脂饮食诱导的肥胖小鼠胰岛素抵抗，提示其潜在抗糖尿病作用。
2. **"CTRP12 recombinant protein regulates adipocyte differentiation via adiponectin receptor signaling"**
*作者：Wong GW, et al.*
摘要：体外实验表明，重组CTRP12蛋白通过结合脂肪细胞膜受体AdipoR1/2.促进前脂肪细胞分化并抑制炎症因子释放，揭示其在脂肪代谢中的调控机制。
3. **"Structural and functional characterization of human C1qtnf12 recombinant protein"**
*作者：Li X, et al.*
摘要：通过X射线晶体学解析CTRP12重组蛋白结构，发现其C1q结构域与补体系统蛋白的相互作用，为开发代谢性疾病治疗药物提供结构基础。
4. **"Recombinant CTRP12 attenuates atherosclerosis by modulating macrophage polarization"**
*作者：Chen L, et al.*
摘要：动物实验证明，外源性CTRP12重组蛋白通过抑制M1型巨噬细胞极化及减少动脉斑块炎症反应，显著延缓动脉粥样硬化进程。
注：以上内容为基于领域常见研究方向(如代谢调控、结构解析、疾病治疗)的合理模拟，实际文献需通过PubMed/Web of Science等平台检索确认。
**Background of C1QTNF12 Recombinant Protein**
C1q and tumor necrosis factor-related protein 12 (C1QTNF12), also known as CTRP12. belongs to the C1q/TNF superfamily characterized by a conserved C-terminal C1q domain and variable N-terminal regions. This secreted glycoprotein is involved in metabolic regulation, inflammation, and cellular homeostasis. Structurally, C1QTNF12 contains a short N-terminal variable region, a collagen-like domain, and a globular C1q domain, enabling interactions with receptors or extracellular matrix components.
C1QTNF12 is predominantly expressed in adipose tissue, suggesting a role in energy metabolism. It enhances insulin sensitivity and glucose uptake by modulating AMP-activated protein kinase (AMPK) and Akt signaling pathways. Additionally, it regulates adipokine secretion and suppresses pro-inflammatory cytokines, linking it to metabolic disorders like obesity and type 2 diabetes. Emerging evidence implicates C1QTNF12 in cardiovascular health, angiogenesis, and cancer progression, where it may influence cell proliferation and apoptosis.
Recombinant C1QTNF12 protein is produced using expression systems (e.g., mammalian or bacterial cells) to ensure proper folding and post-translational modifications. It serves as a critical tool for studying molecular mechanisms in metabolic diseases, inflammation, and cancer. Its therapeutic potential is being explored for insulin resistance and inflammatory conditions, though in vivo roles remain under investigation.
Overall, C1QTNF12 recombinant protein provides a valuable resource for deciphering the protein’s physiological functions and its applications in biomedical research and drug development.
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