| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MTCYB; CYTB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MT-CYB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANXA4抗体的3篇参考文献示例(内容基于公开研究整理，非真实文献)：
1. **文献名称**：*ANXA4 as a Biomarker for Chemoresistance in Ovarian Cancer*
**作者**：Deng, S. et al.
**摘要**：研究通过免疫组化和Western blot分析发现，ANXA4在卵巢癌组织中高表达，并与顺铂耐药性相关。ANXA4抗体被用于检测其在肿瘤细胞膜上的定位，提示其可能作为化疗反应预测的生物标志物。
2. **文献名称**：*ANXA4 Expression in Pancreatic Ductal Adenocarcinoma and Its Clinical Significance*
**作者**：Yokoyama, T. et al.
**摘要**：利用ANXA4抗体对胰腺癌组织进行染色，发现ANXA4高表达与肿瘤转移和不良预后显著相关。研究支持ANXA4作为胰腺癌潜在治疗靶点的可能性。
3. **文献名称**：*Development of a Novel ANXA4 Monoclonal Antibody for Diagnostic Applications*
**作者**：Huang, L. et al.
**摘要**：该研究报道了一种高特异性ANXA4单克隆抗体的开发，验证其在ELISA和免疫荧光中的灵敏度，证实其在结直肠癌早期诊断中的潜在应用价值。
4. **文献名称**：*ANXA4-Mediated Drug Resistance in Colorectal Cancer*
**作者**：Rondepierre, F. et al.
**摘要**：通过ANXA4抗体检测发现，化疗药物5-FU可诱导结直肠癌细胞中ANXA4上调，促进细胞存活和迁移，提示靶向ANXA4可能逆转耐药性。
(注：以上文献为示例，实际引用需以真实发表的论文为准。)
**Background of ANXA4 Antibody**
The ANXA4 antibody targets Annexin A4 (ANXA4), a member of the annexin family of calcium-dependent phospholipid-binding proteins. ANXA4 plays roles in membrane-related processes, including vesicle trafficking, signal transduction, and cell proliferation/apoptosis regulation. It is widely expressed in epithelial tissues, such as the kidney, lung, and gastrointestinal tract, and is implicated in maintaining membrane integrity and calcium homeostasis.
In cancer research, ANXA4 has gained attention due to its overexpression in various malignancies, including ovarian, colorectal, and pancreatic cancers. It is associated with chemoresistance, tumor progression, and metastasis, making it a potential biomarker or therapeutic target. ANXA4 antibodies are essential tools for detecting its expression and localization in cells or tissues via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate ANXA4's role in pathological processes and its interaction with signaling pathways, such as PI3K/AKT and MAPK.
Researchers must validate ANXA4 antibodies for specificity, as isoforms within the annexin family share structural similarities. Applications vary based on antibody clonality (monoclonal vs. polyclonal) and epitope recognition. Reliable ANXA4 antibodies are critical for advancing studies in cancer biology, drug resistance mechanisms, and diagnostic development.
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