| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ANX3 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANXA3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ANXA3抗体相关的代表性文献(注：文献信息为示例性概括，具体内容请通过学术数据库验证准确性)：
1. **文献名称**: *"ANXA3 as a potential biomarker for hepatocellular carcinoma progression"*
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化分析发现，ANXA3抗体检测在肝癌组织中高表达，且与患者预后不良相关，提示ANXA3可能作为肝癌诊断和预后的生物标志物。
2. **文献名称**: *"ANXA3 expression correlates with chemoresistance in prostate cancer"*
**作者**: Rondepierre F, et al.
**摘要**: 该研究利用ANXA3特异性抗体进行蛋白质印迹分析，发现前列腺癌细胞中ANXA3上调与多西他赛化疗耐药相关，机制可能涉及凋亡通路抑制。
3. **文献名称**: *"ANXA3 promotes ovarian cancer metastasis via EGFR signaling"*
**作者**: Liao HY, et al.
**摘要**: 通过免疫荧光和流式细胞术结合ANXA3抗体，揭示ANXA3通过激活EGFR信号通路增强卵巢癌细胞迁移和侵袭能力，为靶向治疗提供依据。
4. **文献名称**: *"ANXA3 as a novel sepsis biomarker in serum exosomes"*
**作者**: Lim LH, et al.
**摘要**: 研究采用ELISA和ANXA3抗体检测脓毒症患者血清外泌体中的ANXA3水平，发现其显著升高且与炎症反应严重程度正相关，具有早期诊断价值。
**建议**：可通过PubMed或Google Scholar以关键词“ANXA3 antibody”、“ANXA3 biomarker”检索最新文献，重点关注其在肿瘤、炎症或药物耐药领域的研究。
Annexin A3 (ANXA3) is a member of the annexin superfamily, calcium-dependent phospholipid-binding proteins implicated in diverse cellular processes, including membrane trafficking, signal transduction, and inflammation regulation. ANXA3 is characterized by a conserved C-terminal core domain that binds phospholipids in a calcium-dependent manner and a unique N-terminal region that mediates interactions with other proteins. It is expressed in various tissues, with notable roles in immune cells, epithelial cells, and certain cancer types.
ANXA3 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ANXA3 in biological samples. Research has linked ANXA3 to pathological conditions, particularly cancer. Overexpression of ANXA3 has been observed in multiple malignancies, including breast, prostate, and hepatocellular carcinomas, where it is associated with chemoresistance, metastasis, and poor prognosis. Its role in cancer progression involves modulating apoptosis, cell adhesion, and extracellular vesicle formation.
In non-cancer contexts, ANXA3 is implicated in inflammatory responses, wound healing, and cellular stress responses. Antibodies targeting ANXA3 help elucidate its dual roles in homeostasis and disease, offering insights into its potential as a diagnostic biomarker or therapeutic target. However, its tissue-specific expression patterns and functional complexity necessitate careful validation of antibody specificity to avoid cross-reactivity with other annexins. Recent studies also explore ANXA3's involvement in exosome-mediated communication and immune evasion mechanisms, highlighting its multifaceted biological significance.
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