Mouse Monoclonal PDXK Antibody

The PDXK (Pyridoxal Kinase) antibody is a tool used to study the enzyme responsible for phosphorylating vitamin B6 vitamers (pyridoxal, pyridoxine, and pyridoxamine) into their active coenzyme form, pyridoxal 5'-phosphate (PLP). PDXK plays a critical role in cellular metabolism, as PLP is a cofactor for over 160 enzymes involved in amino acid, neurotransmitter, and lipid metabolism. Research on PDXK has gained interest due to its implications in neurological disorders, cancer, and metabolic diseases. Antibodies targeting PDXK enable the detection and quantification of the enzyme in tissues or cells, aiding in studies of its expression patterns, subcellular localization, and regulatory mechanisms. For example, altered PDXK levels have been linked to vitamin B6 deficiency-related pathologies, chemotherapy resistance in cancers, and neurodegenerative conditions like Parkinson’s disease. These antibodies are also used in diagnostic research to explore PDXK as a potential biomarker or therapeutic target. Recent studies highlight PDXK's role in mitochondrial function and cellular stress responses, further driving the need for reliable detection tools. Commercial PDXK antibodies are typically validated in applications such as Western blotting, immunohistochemistry, and ELISA, with specificity confirmed via knockout controls. Their development supports advancing understanding of vitamin B6 metabolism and its broader physiological impacts.