Mouse Monoclonal CCNB3 Antibody

The CCNB3 antibody targets cyclin B3. a regulatory protein involved in cell cycle progression, specifically during the transition from the G2 phase to mitosis. Cyclin B3 (encoded by the *CCNB3* gene) belongs to the cyclin family, which partners with cyclin-dependent kinases (CDKs) to drive cell cycle events. Unlike cyclins B1 and B2. CCNB3 is evolutionarily divergent and predominantly expressed in germ cells, particularly during meiosis. However, aberrant expression has been linked to certain cancers, including a subset of sarcomas. Notably, *CCNB3* gene fusions (e.g., with *SS18* or *YWHAE*) are hallmark genetic alterations in some undifferentiated small round cell sarcomas, contributing to tumorigenesis by disrupting cell cycle control. Antibodies against CCNB3 are critical tools for detecting these fusion proteins in diagnostic pathology, aiding in the distinction of CCNB3-rearranged tumors from histologically similar malignancies. Additionally, research-grade CCNB3 antibodies facilitate studies exploring its role in meiosis, cancer biology, and potential therapeutic targeting. Validation of these antibodies for specificity in immunohistochemistry, Western blotting, or immunofluorescence remains essential due to homology with other cyclins and low endogenous expression in somatic tissues.