| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 3693 |
| clone | 1A4H1 |
| WB Predicted band size | 88kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ITGB5 (AA: extra 50-319) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于ITGB5抗体的3篇参考文献摘要：
1. **"Integrin β5 regulates tumor invasion and EMT through epidermal growth factor receptor signaling in non-small cell lung cancer"**
- 作者：Yang et al.
- 摘要：研究利用ITGB5特异性抗体，发现ITGB5通过EGFR信号通路促进肺癌细胞侵袭和上皮间质转化(EMT)，提示其作为肺癌治疗靶点的潜力。
2. **"Targeting integrin β5 for the treatment of idiopathic pulmonary fibrosis"**
- 作者：Kim et al.
- 摘要：通过阻断ITGB5抗体抑制肺成纤维细胞活化，减少纤维化相关蛋白表达，为肺纤维化提供新型治疗策略。
3. **"Integrin β5 antibody suppresses angiogenesis and tumor growth in glioblastoma models"**
- 作者：Chen et al.
- 摘要：研究表明ITGB5抗体通过抑制血管生成和肿瘤细胞迁移，显著降低胶质母细胞瘤小鼠模型的肿瘤体积，验证其抗肿瘤活性。
4. **"Integrin β5 modulates immune evasion in melanoma by regulating PD-L1 expression"**
- 作者：Wang et al.
- 摘要：利用ITGB5抗体阻断实验，揭示ITGB5通过调控PD-L1表达促进黑色素瘤免疫逃逸，为免疫联合治疗提供依据。
(注：以上文献信息为示例性内容，实际研究中需根据具体论文补充完整信息。)
**Background of ITGB5 Antibody**
The ITGB5 antibody targets integrin beta-5 (ITGB5), a subunit of the αvβ5 heterodimeric integrin receptor. Integrins are transmembrane proteins that mediate cell-cell and cell-extracellular matrix (ECM) interactions, playing critical roles in adhesion, migration, signaling, and tissue homeostasis. ITGB5 pairs exclusively with the αv subunit to form the αvβ5 integrin, which recognizes ligands containing the RGD (Arg-Gly-Asp) motif, such as vitronectin, fibronectin, and TGF-β.
αvβ5 is implicated in diverse biological processes, including angiogenesis, wound healing, and tumor progression. It regulates cellular responses by activating signaling pathways like FAK (focal adhesion kinase) and MAPK, influencing cell survival, proliferation, and epithelial-mesenchymal transition (EMT). Dysregulation of ITGB5 expression or function has been linked to pathologies such as cancer metastasis, fibrosis, and inflammatory diseases.
ITGB5 antibodies are essential tools for studying integrin-mediated mechanisms in research applications like Western blotting, immunofluorescence, flow cytometry, and immunohistochemistry. They help elucidate αvβ5's role in disease models, evaluate its expression patterns in tissues, and explore therapeutic targeting strategies. Monoclonal and polyclonal ITGB5 antibodies are available, often validated for specificity in human, mouse, or rat samples, supporting both basic research and drug development efforts.
×
