Mouse Monoclonal M6PR Antibody

The Mannose-6-Phosphate Receptor (M6PR), also known as the cation-dependent (CD-M6PR) or cation-independent (CI-M6PR) receptor, is a key player in lysosomal enzyme trafficking. Discovered in the 1980s, these receptors bind mannose-6-phosphate (M6P) tags on nascent lysosomal hydrolases in the Golgi apparatus, directing their transport to lysosomes via clathrin-coated vesicles. CD-M6PR (46 kDa) and CI-M6PR (300 kDa) differ in structure and cation dependency but share functional overlap. CI-M6PR also binds IGF-II and participates in extracellular signaling pathways. Dysregulation of M6PRs is linked to lysosomal storage disorders (e.g., I-cell disease) and implicated in cancer, neurodegeneration (e.g., Alzheimer’s), and viral entry mechanisms (e.g., SARS-CoV-2). Antibodies targeting M6PRs are vital tools for studying intracellular trafficking, lysosomal biogenesis, and receptor expression in disease models. They enable visualization of receptor localization via immunofluorescence, quantification by flow cytometry, and functional blocking in mechanistic studies. Therapeutic applications are emerging, particularly in cancer, where M6PR overexpression on tumor cells is exploited for targeted drug delivery using M6P-conjugated therapies. Current research focuses on clarifying receptor isoforms, tissue-specific roles, and their interplay in disease pathogenesis.