| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MUC11; MUC-11; |
| Entrez GeneID | 10071 |
| clone | 2C6E1 |
| WB Predicted band size | 55.8kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MUC12 (AA: extra 371-592) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MUC12抗体的参考文献示例(注：以下内容为模拟示例，实际文献请通过学术数据库检索确认)：
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1. **文献名称**: *"Characterization of a Novel Monoclonal Antibody Against MUC12 for Immunohistochemical Detection in Colorectal Cancer"*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对MUC12胞外结构域的单克隆抗体，验证了其在结直肠癌组织中的特异性染色能力，证明MUC12在癌变组织中高表达，可能作为潜在的肿瘤标志物。
2. **文献名称**: *"MUC12 Expression and Its Role in Gastrointestinal Mucosal Barrier Function"*
**作者**: Lee JH, Kim YS.
**摘要**: 通过MUC12特异性抗体进行免疫印迹和免疫荧光分析，发现MUC12在胃肠道黏膜屏障中参与黏液层形成，其表达异常可能与炎症性肠病相关。
3. **文献名称**: *"Development of a MUC12-Specific Antibody for Early Detection of Ovarian Cancer"*
**作者**: Chen L, et al.
**摘要**: 研究团队开发了一种高灵敏度的抗MUC12多克隆抗体，用于检测卵巢癌患者血清和腹水中的MUC12蛋白，结果显示其可能作为早期诊断的生物标志物。
4. **文献名称**: *"MUC12 in Cancer: Antibody-Based Therapeutic Targeting Strategies"*
**作者**: Gupta R, Bafna S.
**摘要**: 综述了MUC12在多种癌症中的过表达机制，并讨论了基于MUC12抗体的靶向治疗(如抗体-药物偶联物)的临床前研究进展。
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建议通过PubMed、Google Scholar等平台检索真实文献，关键词可尝试 **"MUC12 antibody"** 或 **"MUC12 immunohistochemistry"**。
The MUC12 antibody is designed to target mucin 12 (MUC12), a transmembrane glycoprotein belonging to the mucin family, which plays critical roles in epithelial cell protection, lubrication, and cell signaling. MUC12 is encoded by the *MUC12* gene and is characterized by its heavily glycosylated extracellular domain containing tandem repeat sequences, a hallmark of mucins. While its exact biological functions remain under investigation, MUC12 is implicated in maintaining mucosal barriers and modulating immune responses. Dysregulation of MUC12 expression has been observed in gastrointestinal cancers, including colorectal and gastric cancers, suggesting its potential role as a biomarker or therapeutic target.
Antibodies against MUC12 are primarily used in research to study its expression patterns, localization, and interactions in normal and diseased tissues. These tools enable detection via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF). Developing MUC12-specific antibodies is challenging due to the protein’s high glycosylation and structural variability across individuals. However, advances in epitope mapping and recombinant antibody engineering have improved specificity.
Current studies focus on elucidating MUC12’s involvement in cancer progression, metastasis, and drug resistance, with some evidence linking it to altered cell adhesion and signaling pathways. Clinically, MUC12 antibodies may aid in diagnostic assays or targeted therapies, though further validation is needed. Their utility underscores the growing interest in mucins as multifaceted players in health and disease.
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