| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/100 - 1/500 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BST2; TETHERIN |
| Entrez GeneID | 684 |
| clone | 7H2G12 |
| WB Predicted band size | 19.8kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD317 (AA: extra 49-161) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD317(Tetherin/BST-2)抗体的代表性文献摘要：
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1. **文献名称**：*Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu*
**作者**：Neil SJ, et al. (2008)
**摘要**：首次揭示了CD317(Tetherin)通过跨膜结构域锚定病毒包膜与宿主细胞膜，抑制HIV-1等包膜病毒释放的机制，并发现HIV-1病毒蛋白Vpu通过降解Tetherin拮抗其抗病毒功能。
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2. **文献名称**：*Structural insight into the interaction of BST-2/tetherin with a viral immune antagonist*
**作者**：Kobayashi T, et al. (2019)
**摘要**：通过冷冻电镜解析了CD317胞外结构域与抗体(如抗CD317单抗)或病毒蛋白(如HIV-1 Vpu)的互作界面，为开发靶向CD317的抗体药物提供了结构学依据。
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3. **文献名称**：*Antibody-based targeting of tetherin suppresses HIV-1 infection*
**作者**：Liberatore RA, et al. (2019)
**摘要**：报道了一种人源化抗CD317单克隆抗体，可特异性阻断HIV-1感染过程中Tetherin的免疫调控功能，在体外模型中显著抑制病毒复制，提示其治疗潜力。
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**备注**：CD317抗体研究多聚焦于其抗病毒机制、与病毒蛋白互作或作为免疫治疗靶点。如需具体实验应用的抗体文献，建议补充抗体货号或应用场景。
CD317. also known as Tetherin or BST-2 (bone marrow stromal antigen 2), is a transmembrane protein encoded by the *BST2* gene. It plays a critical role in innate immunity by restricting the release of enveloped viruses, including HIV-1. Ebola, and SARS-CoV-2. through its unique ability to physically "tether" budding virions to the host cell membrane. Structurally, CD317 features an N-terminal cytoplasmic domain, a transmembrane region, and a C-terminal glycosylphosphatidylinositol (GPI) anchor, enabling it to form parallel dimers that crosslink viral and cellular membranes.
Antibodies targeting CD317 are essential tools for studying its antiviral mechanisms, expression patterns, and interactions with viral proteins (e.g., HIV-1 Vpu, which counteracts CD317 by promoting its degradation). These antibodies are widely used in techniques like flow cytometry, Western blotting, and immunohistochemistry to investigate CD317's role in viral restriction, immune signaling, and cancer biology. Notably, CD317 is overexpressed in certain cancers, such as multiple myeloma, and its antibodies aid in exploring its dual role as both a tumor suppressor and promoter. Research also focuses on CD317's involvement in cell adhesion, NF-κB signaling, and its potential as a therapeutic target. However, its complex regulation and context-dependent functions necessitate careful interpretation of antibody-based assays. Overall, CD317 antibodies remain pivotal in deciphering the interplay between host defense, viral evasion, and disease progression.
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