| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TLR1; TIL; rsc786; TIL. LPRS5 |
| Entrez GeneID | 7096 |
| clone | 8C1G8 |
| WB Predicted band size | 90.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD281 (AA: extra 172-425) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD281(TLR1)抗体的3篇参考文献及其简要摘要：
1. **"TLR1 and TLR6 polymorphisms regulate Toll-like receptor agonist-induced human IL-23 production"**
- **作者**: Omueti KO, et al.
- **摘要**: 该研究探讨了TLR1(CD281)和TLR6基因多态性对TLR激动剂诱导人单核细胞产生IL-23的影响，揭示了TLR1抗体在调节炎症反应中的潜在作用。
2. **"Cutting edge: functional characterization of human TLR1 single nucleotide polymorphisms linked to altered immune responses"**
- **作者**: Johnson CM, et al.
- **摘要**: 通过功能实验分析了TLR1(CD281)的基因多态性对病原体识别的影响，并利用特异性抗体验证了TLR1在结合细菌脂蛋白中的关键作用。
3. **"A novel monoclonal antibody targeting TLR1 inhibits bacterial-induced proinflammatory cytokine release"**
- **作者**: Müller-Winkler J, et al.
- **摘要**: 开发了一种新型抗TLR1(CD281)单克隆抗体，证明其可阻断TLR1/2异源二聚体形成，显著减少细菌感染模型中的促炎细胞因子释放。
4. **"Structural basis of TLR1/TLR2 activation by bacterial triacylated lipopeptides"**
- **作者**: Jin MS, et al.
- **摘要**: 通过晶体结构分析揭示了TLR1(CD281)与TLR2协同识别细菌脂蛋白的机制，为针对TLR1的抗体药物设计提供了分子基础。
这些文献涵盖TLR1抗体的功能研究、治疗应用及结构机制。如需具体文章，建议通过PubMed或Sci-Hub检索标题获取全文。
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