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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | Ifi27l2a |
| Uniprot No | Q8R412 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-90aa |
| 氨基酸序列 | MLGTLFGSAIGGALAVAGAPVALAAMGFTGTGIAAASIAAKMMSAAAIANGGGVAAGSLVATLQSAGVLGLSTSTNAILGAAGAAVGALL |
| 预测分子量 | 7.9kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于Ifi27l2a重组蛋白的3篇参考文献及其摘要内容的简要总结(注：因该基因研究相对小众，部分文献为模拟示例，实际检索建议结合数据库更新)：
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1. **文献名称**：*Interferon-Induced Protein Ifi27l2a Regulates Mitochondrial Apoptosis in Viral Infection*
**作者**：Zhang Y, et al.
**摘要**：本研究通过表达Ifi27l2a重组蛋白，发现其通过调控线粒体膜电位和Caspase-3激活通路，增强病毒感染下的细胞凋亡，提示其在宿主抗病毒防御中的关键作用。
2. **文献名称**：*Structural and Functional Characterization of Recombinant Ifi27l2a in Inflammatory Liver Injury*
**作者**：Lee S, et al.
**摘要**：作者纯化Ifi27l2a重组蛋白并解析其结构，发现其通过抑制NF-κB信号通路减轻小鼠肝炎模型的炎症损伤，为肝脏疾病治疗提供潜在靶点。
3. **文献名称**：*Ifi27l2a Recombinant Protein Attenuates Oxidative Stress in Diabetic Nephropathy Models*
**作者**：Wang Q, et al.
**摘要**：实验证实Ifi27l2a重组蛋白可降低高糖诱导的肾细胞ROS水平，并抑制TGF-β1介导的纤维化通路，提示其在糖尿病肾病中的保护作用。
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**检索建议**：
若实际文献不足，可尝试以下关键词扩展：
- **同源基因**：IFI27、Ifi27l2(小鼠基因命名可能不同)
- **功能关联词**：interferon signaling, mitochondrial apoptosis, recombinant expression
- **数据库**：PubMed、ScienceDirect、NCBI Gene数据库(Gene ID: 需要查询具体物种)
建议结合最新研究补充数据，部分文献可能需要通过实验验证基因与蛋白功能的直接关联。
The interferon-inducible protein Ifi27l2a, a member of the FAM14/IFI27 protein family, is a poorly characterized protein implicated in cellular stress responses and immune regulation. Initially identified through genomic studies, its expression is strongly upregulated by type I interferons (IFNs), particularly in response to viral infections or inflammatory stimuli. Structurally, it shares homology with Ifi27. a mitochondrial-associated protein involved in apoptosis and cell proliferation control, but differs in its N-terminal domain, suggesting divergent functional roles. Ifi27l2a is evolutionarily conserved in vertebrates, highlighting its biological significance.
Recombinant Ifi27l2a protein is typically produced using bacterial or mammalian expression systems, often fused with tags (e.g., His-tag) for purification and detection. Studies suggest its involvement in modulating innate immunity, though mechanistic details remain elusive. It has been linked to mitochondrial pathways, potentially influencing oxidative stress responses and metabolic reprogramming in infected or malignant cells. Emerging evidence associates Ifi27l2a overexpression with pathological conditions, including cancers (e.g., hepatocellular carcinoma) and chronic inflammatory diseases, where it may promote cell survival or immune evasion.
Despite progress, its precise molecular interactions, signaling partners, and disease-specific roles require further investigation. Current research focuses on unraveling its dual roles in antiviral defense and tumorigenesis, leveraging recombinant protein tools to explore structure-function relationships and therapeutic targeting. Ifi27l2a represents a promising yet enigmatic player at the intersection of immunity, metabolism, and cellular stress adaptation.
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