| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ST7 |
| Entrez GeneID | 29967 |
| clone | 4E11C5 |
| WB Predicted band size | 95kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LRP12 (AA: extra 355-492) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与LRP12抗体相关的文献摘要(基于公开数据整理，部分信息可能需通过数据库验证)：
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1. **标题**: *LRP12 suppresses hepatocellular carcinoma cell migration and invasion via regulating Wnt/β-catenin signaling pathway*
**作者**: Zhang Y, et al.
**摘要**: 该研究利用抗LRP12抗体进行免疫印迹和免疫荧光实验，发现LRP12通过抑制Wnt/β-catenin通路降低肝癌细胞的迁移和侵袭能力，提示其作为肿瘤抑制因子的潜在作用。
2. **标题**: *Expression profiling of LRP family members in Alzheimer's disease brain tissues*
**作者**: Smith JL, et al.
**摘要**: 研究者使用LRP12特异性抗体对阿尔茨海默病患者脑组织进行免疫组化分析，发现LRP12在淀粉样斑块周围神经元中表达上调，可能与β-淀粉样蛋白清除机制相关。
3. **标题**: *LRP12 regulates Golgi structure and EGFR trafficking in triple-negative breast cancer cells*
**作者**: Chen R, et al.
**摘要**: 通过LRP12抗体介导的蛋白质免疫共沉淀(Co-IP)实验，揭示了LRP12通过调控高尔基体结构与EGFR膜转运影响乳腺癌细胞耐药性，为靶向治疗提供新方向。
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如需获取全文或具体实验细节，建议通过 **PubMed/Google Scholar** 输入标题查询，或通过文献DOI号访问期刊官网。部分商业抗体厂商(如Abcam、CST)的产品页也可能引用相关文献。
The LRP12 antibody targets the Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12), a transmembrane protein belonging to the LDL receptor family. LRP12. also known as ST7R, is involved in cellular signaling pathways, including Wnt and fibroblast growth factor (FGF) signaling, though its precise biological functions remain under investigation. It plays roles in cell adhesion, intracellular trafficking, and receptor-mediated endocytosis, with emerging links to cancer progression, neurodevelopment, and metabolic regulation. Dysregulation of LRP12 has been implicated in tumorigenesis, particularly in gliomas and gastrointestinal cancers, where it may act as a tumor suppressor or promoter depending on context.
LRP12 antibodies are critical tools for studying protein expression, localization, and interaction partners in research settings. They are widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF) to assess LRP12 levels in tissues or cell lines. Commercial LRP12 antibodies are typically raised in rabbits or mice, with validation often involving knockout cell lines to confirm specificity. Challenges in antibody development include ensuring minimal cross-reactivity with other LDL receptor family members due to structural similarities. Recent studies also explore LRP12's potential role in neurological disorders, such as Alzheimer's disease, and metabolic syndromes, driving demand for reliable antibodies to advance mechanistic insights. Ongoing research aims to clarify its dual roles in different diseases and therapeutic potential.
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