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Mouse Monoclonal CD213A1 Antibody

  • 中文名： CD213A1抗体
  • 别    名： IL13RA1; NR4; CT19; IL-13Ra
货号: IPD31567
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500 - 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesIL13RA1; NR4; CT19; IL-13Ra
Entrez GeneID3597
clone8A3E3
WB Predicted band size48.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD213A1 (AA: extra 22-343) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CD213A1(IL13RA1)抗体的3篇参考文献示例，基于公开研究整理：

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1. **文献名称**：*IL-13 Receptor α1 Signaling in Cancer: A Promising Therapeutic Target*

**作者**：Smith J, et al.

**摘要**：研究利用CD213A1特异性抗体，通过免疫组织化学分析发现IL13RA1在多种实体瘤中过表达，并探讨其作为免疫治疗靶点的潜力，尤其在调节肿瘤微环境中的作用。

2. **文献名称**：*Monoclonal Antibodies Targeting IL13RA1 Suppress Allergic Asthma in Murine Models*

**作者**：Zhang Y, et al.

**摘要**：开发了一种抗CD213A1的单克隆抗体，通过阻断IL-13与受体的结合，显著减轻小鼠模型中的气道高反应性和炎症反应，验证了其治疗Th2相关疾病的可行性。

3. **文献名称**：*Structural Insights into IL13RA1/IL4R Heterodimerization Using Epitope-Specific Antibodies*

**作者**：Lee S, Kim D.

**摘要**：利用表位特异性CD213A1抗体解析IL13RA1与IL4Rα的异源二聚化机制，揭示了IL-13信号通路的分子基础，为开发靶向抑制剂提供结构依据。

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注：上述文献为示例性质，实际引用需以具体论文为准。建议通过PubMed或Google Scholar搜索“CD213A1 antibody”或“IL13RA1 antibody”获取真实文献。

背景信息

The CD213A1 antibody targets the interleukin-13 receptor subunit alpha-1 (IL-13Rα1), a key component of the type II IL-13 receptor complex. IL-13Rα1 pairs with IL-4Rα to form a heterodimeric receptor that binds IL-13 and IL-4. cytokines central to T helper 2 (Th2)-mediated immune responses. This receptor is implicated in allergic inflammation, asthma, and fibrotic diseases, making it a therapeutic target. CD213A1 antibodies are tools for studying IL-13/IL-4 signaling pathways, often used to block receptor activation or detect expression in immune cells (e.g., B cells, macrophages) and epithelial tissues. Research highlights its role in cancer, as IL-13Rα1 is overexpressed in certain tumors, suggesting utility in targeted therapies or diagnostics. Commercial CD213A1 antibodies enable applications like flow cytometry, immunohistochemistry, and functional assays. Current studies focus on modulating IL-13Rα1 activity to treat autoimmune disorders or enhance antitumor immunity, though clinical translation requires further validation of specificity and safety profiles.

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