| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2 |
| Entrez GeneID | 3588 |
| clone | 1D12C12 |
| WB Predicted band size | 37kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL10RB (AA: extra 20-220) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IL10RB抗体的3篇参考文献，按格式要求整理：
1. **标题**: "Monoclonal Antibody Targeting IL-10 Receptor Beta Chain for Inflammatory Bowel Disease Therapy"
**作者**: Smith A, et al.
**摘要**: 研究开发了一种靶向IL10RB的单克隆抗体，通过阻断IL-10信号通路抑制肠道炎症，在小鼠结肠炎模型中显著减轻炎症反应，提示其治疗IBD的潜力。
2. **标题**: "IL10RB-Specific Antibody Enhances Antitumor Immunity by Reprogramming Tumor-Associated Macrophages"
**作者**: Chen L, et al.
**摘要**: 该文献报道了一种抗IL10RB抗体通过阻断IL-10介导的免疫抑制信号，重编程肿瘤相关巨噬细胞为促炎表型，增强T细胞抗肿瘤活性，为癌症免疫治疗提供新策略。
3. **标题**: "Structural and Functional Characterization of Anti-IL10RB Antibodies in Autoimmune Disorders"
**作者**: Wang Y, et al.
**摘要**: 通过晶体结构解析揭示了抗IL10RB抗体的结合表位，并证明其能有效抑制IL-10信号传导，在类风湿性关节炎模型中降低促炎细胞因子水平，验证其治疗自身免疫疾病的可行性。
(注：上述文献为虚拟示例，实际检索需通过PubMed等数据库获取真实数据。)
The IL10RB antibody targets the interleukin-10 receptor subunit beta (IL10RB), a critical component of the IL-10 receptor complex. IL10RB, encoded by the *IL10RB* gene, pairs with IL10RA to form a heterodimeric receptor that binds IL-10. a potent anti-inflammatory cytokine. This interaction activates the JAK-STAT signaling pathway, primarily STAT3. to suppress pro-inflammatory responses and regulate immune homeostasis. IL10RB is expressed on immune cells, including macrophages, T cells, and B cells, and plays a role in mitigating excessive inflammation in conditions like inflammatory bowel disease (IBD), psoriasis, and autoimmune disorders.
Mutations in *IL10RB* are linked to severe early-onset IBD and immunodeficiency, highlighting its clinical relevance. IL10RB antibodies are essential tools in research to study receptor expression, signaling mechanisms, and dysregulation in disease models. They are used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to quantify protein levels or localize IL10RB in tissues. Monoclonal antibodies against IL10RB also hold therapeutic potential, with investigations exploring their use in blocking aberrant IL-10 signaling or modulating immune responses in cancer and chronic inflammation. Understanding IL10RB's role through antibody-based assays continues to advance insights into immune regulation and therapeutic targeting.
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