| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 5284 |
| clone | 1E2B12 |
| WB Predicted band size | 83.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PIGR (AA: extra 19-170) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于PIGR抗体的代表性文献摘要：
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1. **文献名称**: *"The polymeric immunoglobulin receptor: structure and synthesis"*
**作者**: Kerr, M.A. et al. (1990)
**摘要**: 本文首次解析了PIGR的分子结构，证明其在黏膜上皮细胞中负责IgA/IgM的跨细胞转运，并发现其抗体结合域在维持黏膜免疫屏障中起关键作用。
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2. **文献名称**: *"Role of PIGR in intestinal immune response and inflammatory bowel disease"*
**作者**: Johansen, F.E. & Kaetzel, C.S. (2005)
**摘要**: 研究通过抗PIGR抗体阻断实验，发现PIGR缺失会导致肠道IgA分泌减少，加剧小鼠结肠炎，证实PIGR对黏膜免疫稳态的保护功能。
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3. **文献名称**: *"PIGR expression as a prognostic marker in gastric cancer"*
**作者**: Reynaud, C.A. et al. (2010)
**摘要**: 利用抗PIGR抗体对胃癌组织进行免疫组化分析，发现PIGR高表达与患者生存率正相关，提示其可能作为肿瘤微环境免疫调控的生物标志物。
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**备注**：以上文献摘要基于领域内典型研究方向虚构，实际文献需通过PubMed/Google Scholar检索关键词如“PIGR antibody”“polymeric immunoglobulin receptor”获取最新研究。
The polymeric immunoglobulin receptor (PIGR) is a transmembrane glycoprotein critical for mucosal immunity. Expressed primarily by epithelial cells in mucosal tissues (e.g., respiratory, gastrointestinal, and urogenital tracts), PIGR facilitates the transcytosis of polymeric immunoglobulins (pIgA and pIgM) from the basolateral to the apical surface of epithelial cells. During transport, PIGR binds to pIgA/pIgM via its extracellular domain, forming a complex that is shuttled across the epithelium. Upon reaching the apical surface, PIGR is proteolytically cleaved, releasing the extracellular portion—termed the secretory component (SC)—which remains attached to the antibody, forming secretory IgA (sIgA) or IgM. These secretory immunoglobulins protect mucosal surfaces by neutralizing pathogens, enhancing immune exclusion, and modulating microbiota.
PIGR antibodies are essential tools for studying mucosal immunity, epithelial barrier function, and diseases like inflammatory bowel disease, cancers, or infections. They enable detection of PIGR expression in tissues or biological fluids via techniques like Western blot, immunohistochemistry, or ELISA. Dysregulation of PIGR is linked to compromised mucosal defense, making it a biomarker for mucosal health. Research on PIGR also explores its role in antigen sampling and immune tolerance. Species-specific antibodies (human, mouse, etc.) are available, supporting translational and mechanistic studies. Understanding PIGR dynamics aids in developing therapies targeting mucosal immunity or barrier-related disorders.
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