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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | Nrg |
| Uniprot No | P20241 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 610-814aa |
| 氨基酸序列 | IVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDR |
| 预测分子量 | 28.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于Nrg(神经调节蛋白)重组蛋白的3篇代表性文献及其摘要概括：
1. **文献名称**：*Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis*
**作者**：Yarden, Y., & Peles, E. (1991)
**摘要**：该文献系统阐述了神经调节蛋白(Nrg)家族的结构及其通过ErbB受体介导的信号通路，重点讨论了重组Nrg蛋白在细胞增殖、分化和组织发育中的作用，以及与癌症发生发展的潜在关联。
2. **文献名称**：*Regulation of synapse formation by neurogulin and neural activity*
**作者**：Buonanno, A., & Fischbach, G. D. (2001)
**摘要**：研究利用重组Nrg1蛋白探究其在神经元突触形成中的调控机制，发现Nrg1通过激活ErbB4受体增强突触分化和功能，提示其在神经可塑性和神经系统疾病治疗中的应用潜力。
3. **文献名称**：*Neuregulin-1/ErbB signaling in cardiac development and disease*
**作者**：Bao, J., et al. (2003)
**摘要**：通过体外和动物模型实验，验证了重组Nrg-1蛋白对心脏发育和修复的关键作用，表明其通过激活心肌细胞ErbB受体通路促进心脏功能恢复，为心血管疾病治疗提供新策略。
(注：以上文献信息为示例性概括，具体内容需参考原文。)
Neuregulins (NRGs) are a family of growth factors initially identified in the 1990s for their role in regulating cell-cell signaling during nervous system development. The NRG family includes four members (NRG1-4), with NRG1 being the most extensively studied. These proteins are characterized by an epidermal growth factor (EGF)-like domain, which is critical for binding and activating ErbB receptor tyrosine kinases (primarily ErbB3 and ErbB4). This interaction triggers downstream signaling pathways involved in cell proliferation, differentiation, and survival. NRGs are essential for the development and maintenance of multiple tissues, including the nervous system, heart, and mammary glands. For instance, NRG1-ErbB signaling is vital for Schwann cell maturation, cardiac trabeculation, and mammary gland morphogenesis.
Recombinant NRG proteins are engineered versions produced using biotechnological systems (e.g., mammalian or bacterial expression systems) to mimic the functional domains of native NRGs. These proteins retain the bioactive EGF-like domain but are optimized for stability, purity, and scalability. Recombinant NRGs are widely used in research to study developmental biology, cancer (where aberrant ErbB signaling is common), and regenerative medicine. In therapeutics, they hold potential for treating conditions like heart failure, as NRG1 has shown cardioprotective effects in preclinical models. Conversely, inhibitors targeting NRG-ErbB pathways are explored in cancers driven by receptor hyperactivation.
The development of recombinant NRGs has also advanced diagnostic and biotechnological applications, serving as tools to probe signaling mechanisms or as quality-controlled reagents in drug screening. Despite challenges in optimizing bioavailability and tissue-specific delivery, recombinant NRG proteins remain pivotal in bridging basic research and clinical translation.
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