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Mouse Monoclonal GLRB Antibody

  • 中文名： GLRB抗体
  • 别    名： HKPX2
货号: IPD31289
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/200 - 1/1000 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesHKPX2
Entrez GeneID2743
clone3B8A8
WB Predicted band size56.1kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GLRB (AA: extra 23-160) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于GLRB抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：

1. **文献名称**：*Glycine Receptor β-Subunit Antibody Characterization in Spinal Cord Neurons*

**作者**：Smith A, et al.

**摘要**：该研究开发并验证了一种特异性针对甘氨酸受体β亚基(GLRB)的多克隆抗体，通过免疫组化和Western blot分析，证实了其在啮齿类动物脊髓神经元中的高表达，并揭示了GLRB在抑制性突触中的定位。

2. **文献名称**：*Impaired Glycinergic Signaling in GLRB Knockout Mice: An Antibody-Based Study*

**作者**：Chen L, et al.

**摘要**：利用GLRB特异性抗体，本研究在GLRB基因敲除小鼠模型中观察到甘氨酸能传递的显著缺陷，表明GLRB亚基对神经系统的抑制性信号传导至关重要，并可能与运动障碍相关。

3. **文献名称**：*Autoantibodies Targeting GLRB in Neurological Disorders*

**作者**：Wang Y, et al.

**摘要**：该文献报道了在部分自身免疫性神经系统疾病患者血清中检测到抗GLRB抗体，提示此类抗体可能通过干扰甘氨酸受体功能导致突触传递异常，为疾病机制研究提供了新方向。

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*注：以上文献信息为示例性质，实际研究中请通过PubMed或Google Scholar等数据库检索真实文献。*

背景信息

The glycine receptor beta subunit (GLRB) is a key component of inhibitory glycine receptors (GlyRs), which are ligand-gated chloride channels mediating synaptic inhibition in the central nervous system. GlyRs are pentameric complexes typically composed of alpha (α1-α4) and beta (β) subunits, with GLRB forming the structural backbone that anchors receptors to the postsynaptic membrane. GLRB antibodies are immunological tools used to study the expression, localization, and function of GlyRs in neurological tissues. These antibodies have been critical in research on glycinergic neurotransmission, particularly in spinal cord and brainstem circuits regulating motor coordination, pain perception, and respiratory rhythms. Dysfunction of GLRB is linked to hyperekplexia (startle disease), a rare neurological disorder characterized by excessive startle responses and muscle rigidity. Commercially available GLRB antibodies are typically developed in rabbits or mice using synthetic peptides or recombinant proteins corresponding to specific extracellular or intracellular domains. Validation methods include Western blotting, immunohistochemistry, and knockout tissue controls. Recent applications extend to investigating GlyR involvement in neurodevelopmental disorders, chronic pain mechanisms, and neurodegenerative conditions. Proper antibody selection requires attention to species reactivity, epitope specificity, and experimental compatibility.

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