Mouse Monoclonal ALDOA Antibody

The ALDOA antibody targets aldolase A, a glycolytic enzyme encoded by the *ALDOA* gene, which plays a central role in glucose metabolism by catalyzing the cleavage of fructose-1.6-bisphosphate into triose phosphates. Primarily expressed in muscle tissues and erythrocytes, ALDOA also exhibits non-glycolytic functions, including regulation of cytoskeletal dynamics and cellular stress responses. Dysregulation of ALDOA is associated with various pathologies, such as glycogen storage disease XII (caused by *ALDOA* mutations), cancer progression (e.g., enhanced expression in lung, liver, and pancreatic tumors), and muscle disorders. ALDOA antibodies are widely used in research to study its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate its role in metabolic reprogramming in cancers or muscle degeneration mechanisms. Commercially available ALDOA antibodies are typically monoclonal or polyclonal, validated for specificity across human and model organisms. Recent studies also explore ALDOA as a potential diagnostic biomarker or therapeutic target, underscoring its clinical relevance. However, interpretation requires caution due to isoform cross-reactivity (e.g., aldolase B/C) in some antibody batches.