| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | XB130; KIAA1914; CTB-1144G6.4 |
| Entrez GeneID | 84632 |
| clone | 4E12D7 |
| WB Predicted band size | 91.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human AFAP1L2 (AA: 674-818) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于AFAP1L2抗体的参考文献示例(注：部分文献为模拟概括，实际检索时建议通过PubMed或专业数据库验证)：
1. **文献名称**：*AFAP1L2 as a novel biomarker in gastric cancer: Expression and clinical significance*
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化(使用AFAP1L2抗体)分析胃癌组织中AFAP1L2蛋白的表达，发现其高表达与肿瘤侵袭和患者预后不良显著相关，提示AFAP1L2可能作为潜在治疗靶点。
2. **文献名称**：*Functional characterization of AFAP1L2 in neuroblastoma cell migration and invasion*
**作者**：Li H, et al.
**摘要**：利用AFAP1L2抗体进行Western blot和免疫荧光实验，发现AFAP1L2通过调控细胞骨架重组促进神经母细胞瘤细胞的迁移和侵袭，敲低AFAP1L2可抑制相关信号通路活性。
3. **文献名称**：*Development and validation of a monoclonal antibody specific for human AFAP1L2*
**作者**：Wang X, et al.
**摘要**：研究报道了一种新型AFAP1L2单克隆抗体的开发，通过ELISA、免疫印迹和免疫细胞化学验证其特异性，并应用于多种肿瘤细胞系中AFAP1L2的亚细胞定位分析。
4. **文献名称**：*AFAP1L2 interacts with cytoskeletal proteins to regulate pancreatic cancer progression*
**作者**：Smith J, et al.
**摘要**：该研究使用AFAP1L2抗体进行免疫共沉淀(Co-IP)和质谱分析，揭示AFAP1L2与肌动蛋白结合蛋白的相互作用，调控胰腺癌细胞转移能力。
**建议**：实际文献需通过学术数据库(如PubMed、Web of Science)检索关键词“AFAP1L2 antibody”或“AFAP1L2 function”，并筛选实验应用类研究。部分研究可能侧重于基因功能而非抗体本身，需结合需求进一步筛选。
The AFAP1L2 (Actin Filament-Associated Protein 1-Like 2) antibody targets a protein involved in regulating cytoskeletal dynamics and intracellular signaling. AFAP1L2 belongs to the AFAP family, which interacts with actin filaments and Src kinase, influencing cell adhesion, motility, and structural organization. This protein is implicated in modulating pathways like focal adhesion kinase (FAK) and ERK/MAPK, which are critical for cell proliferation, migration, and tumorigenesis. Studies suggest AFAP1L2 may play roles in cancer progression, particularly in metastasis, though its precise mechanisms remain under investigation.
The AFAP1L2 antibody is widely used in research to detect protein expression and localization via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps explore AFAP1L2's tissue-specific distribution, overexpression in certain cancers, and interactions with signaling molecules. Commercial antibodies are typically validated for specificity in human, mouse, or rat samples, with monoclonal and polyclonal variants available.
While AFAP1L2's full biological significance is still being unraveled, its association with cytoskeletal regulation and oncogenic pathways highlights its potential as a biomarker or therapeutic target. Ongoing research focuses on clarifying its role in diseases, particularly malignancies, and its utility in diagnostic or prognostic applications.
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