| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CD163L1 |
| Uniprot No | Q9NR16 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 48-469aa |
| 氨基酸序列 | LRLVNGDGPCSGTVEVKFQGQWGTVCDDGWNTTASTVVCKQLGCPFSFAMFRFGQAVTRHGKIWLDDVSCYGNESALWECQHREWGSHNCYHGEDVGVNCYGEANLGLRLVDGNNSCSGRVEVKFQERWGTICDDGWNLNTAAVVCRQLGCPSSFISSGVVNSPAVLRPIWLDDILCQGNELALWNCRHRGWGNHDCSHNEDVTLTCYDSSDLELRLVGGTNRCMGRVELKIQGRWGTVCHHKWNNAAADVVCKQLGCGTALHFAGLPHLQSGSDVVWLDGVSCSGNESFLWDCRHSGTVNFDCLHQNDVSVICSDGADLELRLADGSNNCSGRVEVRIHEQWWTICDQNWKNEQALVVCKQLGCPFSVFGSRRAKPSNEARDIWINSISCTGNESALWDCTYDGKAKRTCFRRSDAGVICS |
| 预测分子量 | 54.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CD163L1重组蛋白的3篇文献示例(注：部分文献为虚拟示例，实际需通过数据库验证)：
1. **《Structural characterization of recombinant porcine CD163L1 and its interaction with PRRSV》**
- 作者：Smith A, et al.
- 摘要：研究通过重组表达纯化了猪源CD163L1胞外结构域，解析其晶体结构，并证明其与猪繁殖与呼吸综合征病毒(PRRSV)表面蛋白的相互作用，为抗病毒药物设计提供依据。
2. **《CD163L1 as a potential innate immune checkpoint in macrophages》**
- 作者：Lee J, et al.
- 摘要：利用重组人CD163L1蛋白研究其在巨噬细胞中的免疫调节功能，发现其通过调控炎症因子释放参与宿主抗感染反应，提示其作为免疫治疗靶点的潜力。
3. **《Comparative analysis of CD163 and CD163L1 in viral entry pathways》**
- 作者：Gomez-Ramirez C, et al.
- 摘要：通过重组蛋白实验比较CD163和CD163L1在介导病毒进入宿主细胞中的差异，发现CD163L1对特定冠状病毒的亲和力更高，可能解释其组织特异性感染机制。
*提示*：实际引用时建议通过PubMed或Web of Science检索最新文献，关键词包括"CD163L1 recombinant protein"、"sCD163L1"或结合具体研究领域(如病毒学、炎症调控)。部分研究可能侧重其作为清道夫受体的功能或与CD163的功能对比。
CD163L1 (CD163 molecule-like 1) is a transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily, closely related to CD163. Both proteins are predominantly expressed on monocytes/macrophages and play roles in innate immunity, particularly in resolving inflammation and host-pathogen interactions. CD163L1 shares structural homology with CD163. featuring multiple SRCR domains in its extracellular region, which mediate ligand recognition. However, unlike CD163. which is well-characterized as a hemoglobin-haptoglobin scavenger receptor, CD163L1’s precise biological functions remain less defined. Emerging studies suggest it may act as a co-receptor or alternative receptor for pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV) in swine, and potentially modulate inflammatory responses.
Recombinant CD163L1 protein is engineered to study its molecular interactions, structural properties, and therapeutic potential. It is typically produced in mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications. The purified protein often includes the extracellular domain, enabling research into ligand binding, receptor-ligand kinetics, and immune signaling pathways. Applications span virology (exploring viral entry mechanisms), immunology (elucidating anti-inflammatory roles), and drug development (targeting receptor-mediated pathways). Recent interest also focuses on its potential as a biomarker or therapeutic target in inflammatory diseases, infections, or cancer. However, functional redundancy with CD163 and species-specific variations necessitate careful experimental design in translational studies.
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