| WB | 咨询技术 | Human,Monkey |
| IF | 咨询技术 | Human,Monkey |
| IHC | 咨询技术 | Human,Monkey |
| ICC | 技术咨询 | Human,Monkey |
| FCM | 1/200 - 1/400 | Human,Monkey |
| Elisa | 1/10000 | Human,Monkey |
| Aliases | CR; CAL2; CAB29 |
| Entrez GeneID | 794 |
| clone | 7H1G3 |
| WB Predicted band size | 31.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Monkey |
| Immunogen | Purified recombinant fragment of human CALB2 (AA: 172-271) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CALB2(Calretinin)抗体的3篇代表性文献示例(注：文献信息为示例性概括，具体文献需根据实际检索结果调整)：
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1. **文献名称**：*Calretinin immunoreactivity in the mammalian retina and its relation to cell types*
**作者**：Wouterloot FG, J.K.
**摘要**：本研究利用CALB2抗体标记哺乳动物视网膜中的特定神经元亚群，揭示了其在双极细胞和无长突细胞中的差异性表达，为视网膜神经环路的功能研究提供了形态学依据。
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2. **文献名称**：*Characterization of a polyclonal antibody to human calretinin: Diagnostic utility in neuropathology*
**作者**：Jacobowitz DM, Winsky L.
**摘要**：文章系统验证了一种多克隆CALB2抗体的特异性，证明其在人脑组织(如海马和新皮质)中可特异性标记中间神经元，并探讨了其在阿尔茨海默病等神经退行性疾病病理诊断中的潜在应用。
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3. **文献名称**：*Calretinin as a marker for mesothelioma in effusion cytology*
**作者**：Pellissier V, et al.
**摘要**：该研究通过CALB2抗体检测胸腔积液中的间皮瘤细胞，证明其作为免疫组化标志物在区分恶性间皮瘤与腺癌中的高敏感性和特异性，为临床病理诊断提供了重要工具。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“CALB2 antibody”、“Calretinin immunohistochemistry”或结合研究领域(如神经科学、癌症诊断)筛选近年研究。
**Background of CALB2 (Calretinin) Antibody**
CALB2. also known as calretinin, is a calcium-binding protein belonging to the EF-hand protein family, encoded by the *CALB2* gene. It plays a role in regulating intracellular calcium signaling, influencing processes like neurotransmission, cell differentiation, and apoptosis. Calretinin is widely expressed in the central and peripheral nervous systems, particularly in GABAergic neurons, retinal cells, and sensory ganglia, where it modulates neuronal excitability and synaptic plasticity.
In diagnostic pathology, CALB2 antibodies are essential immunohistochemical markers. They are routinely used to identify mesothelial cells (e.g., in mesothelioma diagnosis) and distinguish them from adenocarcinoma, as calretinin is highly expressed in mesothelial tissues. Additionally, these antibodies help characterize certain neural tumors, sex cord-stromal tumors of the ovary, and adrenocortical lesions.
Research applications include studying neurodevelopmental and neurodegenerative disorders, such as Alzheimer’s disease, where altered calretinin expression has been observed. CALB2 antibodies are typically monoclonal (e.g., clone DAK-Calret 1) and validated for formalin-fixed, paraffin-embedded tissues, ensuring specificity for the 29-31 kDa protein. Their utility in both research and diagnostics underscores their importance in understanding cellular calcium dynamics and disease mechanisms.
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